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DISP1 Antibody

  • WB - DISP1 Antibody ASC11417
    Western blot analysis of DISP1 in 3T3 cell lysate with DISP1 antibody at 1 µg/mL.
  • IHC - DISP1 Antibody ASC11417
    Immunohistochemistry of DISP1 in human kidney tissue with DISP1 antibody at 2.5 µg/mL.
  • IF - DISP1 Antibody ASC11417
    Immunofluorescence of DISP1 in human kidney tissue with DISP1 antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q96F81
Other Accession NP_116279, 25952134
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 170934 Da
Application Notes DISP1 antibody can be used for detection of DISP1 by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 84976
Target/Specificity DISP1; At least two isoforms of DISP1 are known to exist; this antibody will detect both isoforms. DISP1 antibody is predicted to not cross-react with EMX1.
Reconstitution & Storage DISP1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsDISP1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DISP1
Synonyms DISPA
Function Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal (By similarity). Synergizes with SCUBE2 to cause a increase in SHH secretion (PubMed:22902404).
Cellular Location Membrane; Multi-pass membrane protein
Research Areas
Citations (0)

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DISP1 Antibody: DISP1 is the mammalian homolog of the Drosophila Dispatched segment-polarity gene and a key regulator of the Hedgehog (Hh) signaling pathway during embryonic development. DISP1 is required to move Shh from site of synthesis during embryogenesis; mutations in the gene result in lethality at mid-gestation and prevents specification of ventral cell types in the neural tube. Recent results have shown that DISP1 mediates the basolateral secretion of Shh and regulates growth of mammalian long bones through the control of Ihh.


Caspary T, Garcia-Garcia MJ, Huangfu D, et al. Mouse dispatched homolog1 is required for long-range, but not juxtacrine, Hh signaling. Curr. Biol. 2002; 12:1628-32
Etheridge LA, Crawford TQ, Zhang S, et al. Evidence for a role of vertebrate Disp1 in long-range Shh signaling. Development 2010; 137:133-40.
Tsiairis CD and McMahon AP. Disp1 regulates growth of mammalian long bones through the control of Ihh distribution. Dev. Biol. 2008; 317:480-5.

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$ 335.00
Cat# ASC11417
Availability: 5-7days
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