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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   SDHD Antibody   

SDHD Antibody

  • WB - SDHD Antibody ASC11485
    Western blot analysis of SDHD in EL4 cell lysate with SDHD antibody at (A) 1 and (B) 2 µg/mL.
  • ICC - SDHD Antibody ASC11485
    Immunocytochemistry of SDHD in EL4 cells with SDHD antibody at 2.5 µg/mL.
  • IF - SDHD Antibody ASC11485
    Immunofluorescence of SDHD in EL4 cells with SDHD antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O14521
Other Accession NP_002993, 9392
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 17043 Da
Application Notes SDHD antibody can be used for detection of SDHD by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunocytochemistry starting at 2.5 μg/mL. For immunofluorescence start at 2.5 μg/mL.
Additional Information
Gene ID 9392
Target/Specificity SDHD antibody was raised against a 15 amino acid synthetic peptide near the center of human SDHD.

The immunogen is located within amino acids 30 - 80 of SDHD.
Reconstitution & Storage SDHD antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsSDHD Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms SDH4
Function Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
Cellular Location Mitochondrion inner membrane; Multi-pass membrane protein
Research Areas
Citations (0)

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SDHD Antibody: The mitochondrial succinate dehydrogenase complex subunit D (SDHD) is one of four proteins that make up the tricarboxylic cycle enzyme succinate dehydrogenase (SCH). Studies have shown that mutations in SDHD often leads to hereditary paragangliomas, usually benign tumors of the autonomic nervous system, suggesting that SDHD also plays a role as a tumor-suppressor gene. In one family with a nonsense mutation (R22X) in the SDHD gene, a loss of heterozygosity was found in the paragangliomas, and within these tumors the enzymatic activity of Complex II in the mitochondrial respiratory chain was completely abolished. Furthermore, high levels of angiogenic factors EPAS1 and VEGF was observed, which may stimulate tumor growth.


Baysal BE, Ferrell RE, Willett-Brozick JE, et al. Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma. Science 2000; 287:848-51.
Saraste M. Oxidative phosphorylation at the fin de siecle. Science 1999; 283:1488-93.
Knudson AG. Genetics of human cancer. Annu. Rev. Genet. 1986; 20:231-51.
Gimenez-Roqueplo AP, Favier J, Rustin P, et al. The R22X mutation of the SDHD gene in hereditary paraganglioma abolishes the enzymatic activity of Complex II in the mitochondrial respiratory chain and activates the hypoxia pathway. Am. J. Hum. Genet. 2001; 69:1186-97.

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$ 335.00
Cat# ASC11485
Availability: 5-7days
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