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LEMD2 Antibody

  • WB - LEMD2 Antibody ASC11495
    Western blot analysis of LEMD2 in 293 cell lysate with LEMD2 antibody at (A) 1 and (B) 2 µg/mL.
  • ICC - LEMD2 Antibody ASC11495
    Immunocytochemistry of LEMD2 in 3T3 cells with LEMD2 antibody at 2.5 µg/mL.
  • IF - LEMD2 Antibody ASC11495
    Immunofluorescence of LEMD2 in 3T3 cells with LEMD2 antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8NC56
Other Accession NP_851853, 31044432
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 56975 Da
Application Notes LEMD2 antibody can be used for detection of LEMD2 by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunocytochemistry starting at 2.5 µg/mL. For immunofluorescence start at 2.5 µg/mL.
Additional Information
Gene ID 221496
Target/Specificity LEMD2; At least two isoforms of LEMD2 are known to exist; this antibody will detect only the longer isoform.
Reconstitution & Storage LEMD2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsLEMD2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LEMD2
Function Involved in nuclear structure organization (PubMed:16339967). Required for maintaining the integrity of the nuclear envelope (PubMed:17097643).
Cellular Location Nucleus inner membrane; Multi- pass membrane protein. Note=Lamina- associated protein residing in the inner nuclear membrane (INM) Localized exclusively to the nuclear envelope, giving rise to a typical rim-like staining of the nuclear periphery
Tissue Location Ubiquitously expressed.
Research Areas
Citations (0)

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LEMD2 Antibody: The LEM (lamina-associated polypeptide-emerin-MAN1) domain is a motif shared by a group of lamin-interacting proteins of the inner nuclear membrane (INM) and nucleoplasm. One such protein, LEMD2 (LEM domain-containing protein 2), is a lamina-associated protein in the INM involved in nuclear structure organization, containing an N-terminal LEM motif, two transmembrane domains, and a MAN1-Src1p C-terminal (MSC) domain. LEMD2 is a truncated paralog of MAN1, lacking the MAN1-specific C-terminal RNA-recognition motif, but like MAN1 is required for myogenic differentiation. Mutations in LEMD2 are thought be among the possible causes of muscle disease.


Brachner A, Reipert S, Foisner R, et al. LEM2 is a novel MAN1-related inner nuclear membrane protein associated with A-type lamins. J. Cell Sci. 2005; 118:5797-810
Huber MD, Guan T, and Gerace L. Overlapping functions of nuclear envelope proteins NET25 (Lem2) and Emerin in regulation of extracellular signal-regulated kinase signaling in myoblast differentiation. Mol. Cell. Biol. 2009; 29:5718-28.

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$ 335.00
Cat# ASC11495
Availability: 5-7days
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