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FRL1 Antibody

  • WB - FRL1 Antibody ASC11576
    Western blot analysis of FRL1 in EL4 cell lysate with FRL1 antibody at 1 µg/mL.
  • IF - FRL1 Antibody ASC11576
    Immunofluorescence of FRL1 in EL4 cells with FRL1 antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O95466
Other Accession NP_005883, 33356148
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 121 kDa
Application Notes FRL1 antibody can be used for detection of FRL1 by Western blot at 1 - 2 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 752
Target/Specificity FMNL1; FRL1 antibody is human, mouse and rat reactive. Three alternatively spliced transcript variants have been observed
Reconstitution & Storage FRL1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsFRL1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FMNL1
Synonyms C17orf1, C17orf1B, FMNL, FRL1
Function May play a role in the control of cell motility and survival of macrophages (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape.
Cellular Location Cytoplasm. Cell membrane; Lipid-anchor. Cytoplasmic vesicle, phagosome. Note=Recruited to actin-rich phagosomes during phagocytosis. Translocates to the plasma membrane upon activation by RAC1 (By similarity).
Tissue Location Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas
Research Areas
Citations (0)

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FRL1 Antibody: The Formin-like protein 1 (FRL1) gene encodes a formin-related protein which has been implicated in morphogenesis, cyokinesis, and cell polarity. Formins are a conserved class of proteins expressed in all eukaryotes and have one DAD (diaphanous autoregulatory domain), one FH2 (formin homology 2) domain and one GBD/FH3 (Rho GTPase-binding / formin homology 3) domain. FRL1 is located in the cytoplasm and is highly expressed in the spleen, lymph node and bone marrow cells. FRL1 possibly has a role in the control of cell motility, survival of macrophages and cytoskeletal organization.


Katoh M and Katoh M. Identification and characterization of human FMNL1, FMNL2 and FMNL3 genes in silico. Int. J. Oncol. 2003; 22:1161-8.
Yayoshi-Yamamoto S, Taniuchi I and Watanabe T. FRL, a novel formin-related protein, binds to Rac and regulates cell motility and survival of macrophages. Mol. Cell. Biol. 2000; 20: 6872-81.
Favaro PM, Traina F, Vassallo J, et al. High expression of FMNL1 protein in T non-Hodgkin’s lymphomas. Leuk. Res. 2006; 30:735-8.
Gomez TS, Kumar K, Medeiros RB, et al. Formins regulate the actin-related protein 2/3 complex-independent polarization of the centrosome to the immunological synapse. Immunity 2007; 26:177-90.

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$ 335.00
Cat# ASC11576
Availability: 5-7days
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