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TSPY1S Antibody

  • WB - TSPY1S Antibody ASC11583
    Western blot analysis of TSPY1S in A20 cell lysate with TSPY1S antibody at 1 µg/mL in (A) the absence and (B) the presence of blocking peptide.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q01534
Other Accession NP_001184171, 308522758
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 32 kDa
Application Notes TSPY1S antibody can be used for detection of TSPY1S by Western blot at 1 - 2 µg/mL.
Additional Information
Gene ID 7258
Target/Specificity TSPY1; TSPY1S antibody is human and mouse reactive. At least three isoforms of TSPY1 are known to exist; this antibody will detect only TSPY1S
Reconstitution & Storage TSPY1S antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsTSPY1S Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TSPY1
Synonyms TSPY
Function May be involved in sperm differentiation and proliferation.
Cellular Location Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Also found in nucleus
Tissue Location Specifically expressed in testicular tissues. Isoform 1 and isoform 2 are expressed in spermatogonia and spermatocytes. Found in early testicular carcinoma in situ, spermatogonial cells in testicular tissues of 46,X,Y female and in prostate cancer cell lines.
Research Areas
Citations (0)

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TSPY1S Antibody: Testis-specific protein on Y chromosome (TSPY1) is an ampliconic gene on the Y chromosome that has been associated with gonadoblastoma. Recent experiments have shown that in androgen-dependent testicular germ-cell tumors, TSPY1 can repress the androgen-bound androgen receptor (AR), a member of the nuclear steroid hormone receptor family that acts as a ligand-inducible transcription factor, suggesting that TSPY1 is a repressor of cell proliferation in germ-cell tumors and potentially in normal gonadal cells during early development. Two distinct isoforms of TSPY1, TSPY1L and TSPY1S, are known to exist.


Arnemann J, Jakubiczka S, Thuring S, et al. Cloning and sequence analysis of a human Y-chromosome-derived, testicular cDNA, TSPY. Genomics 1991; 11:108-114
Lau YF. Gonadoblastoma, testicular and prostate cancers, and the TSPY gene. Am. J. Hum. Genet. 1999; 64:921-7.
Akimoto C, Ueda T, Inoue K, et al. Testis-specific protein on Y chromosome (TSPY) represses the activity of the androgen receptor in androgen-dependent testicular germ-cell tumors. Proc. Natl. Acad. Sci. USA 2010; 107:19891-6.
Krick R, Jacubiczka S, and Arnemann J. Expression, alternative splicing and haplotype analysis of transcribed testis specific protein (TSPY) genes. Gene 2003; 302:11-9.

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$ 335.00
Cat# ASC11583
Availability: 5-7days
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