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TNFSF4 Antibody

  • WB - TNFSF4 Antibody ASC11620
    Western blot analysis of TNFSF4 in rat spleen tissue lysate with TNFSF4 antibody at (A) 0.5 and (B) 1 µg/mL
  • IHC - TNFSF4 Antibody ASC11620
    Immunohistochemistry of TNFSF4 in spleen tissue with TNFSF4 antibody at 5 µg/ml.
  • IF - TNFSF4 Antibody ASC11620
    Immunofluorescence of TNFSF4 in human spleen tissue with TNFSF4 antibody at 20 µg/ml.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P23510
Other Accession NP_003317, 4507603
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 20 kDa
Application Notes TNFSF4 antibody can be used for detection of TNFSF4 by Western blot at 0.5 - 1 µg/mL.
Additional Information
Gene ID 7292
Target/Specificity TNFSF4; At least two isoforms of TNFSF4 are known to exist; this antibody will detect both isoforms.
Reconstitution & Storage TNFSF4 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsTNFSF4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms TXGP1
Function Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production.
Cellular Location Membrane; Single-pass type II membrane protein
Research Areas
Citations (0)

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TNFSF4 Antibody: The tumor necrosis factor superfamily member TNFSF4 is a type II membrane bound, non-covalently linked homotrimeric protein. It is expressed on antigen presenting cells, such as dendritic cells and activated B-cells, and also on other cells such as vascular endothelial cells, mast cells, and natural killer cells. TNFSF4 signals specifically through the TNFRSF4 receptor, is expressed predominantly on CD4+T cells but also on certain activated CD8+T cells. TNFRSF4/TNFSF4 functions as a costimulatory signal, which is required for a productive interaction between antigen presenting cells and their target T-cells. It enhances cell proliferation and survival, and increases expression of RANTES, IL-2, IL-3, and IFNγ. TNFRSF4/TNFSF4 signaling plays an important role in immunotolerance.


Arch RH and Thompson CB. 4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB. Mol. Cell Biol.1998; 18:558-65.
OX40-OX40 ligand interaction in T-cell-mediated immunity and immunopathy. Adv. Immunol. 2010; 105:63-98

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$ 335.00
Cat# ASC11620
Availability: 5-7days
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