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PTRF Antibody

  • WB - PTRF Antibody ASC11629
    Western blot analysis of PTRF in human spleen tissue lysate with PTRF antibody at (A) 0.5 and (B) 1 µg/mL
  • IHC - PTRF Antibody ASC11629
    Immunohistochemistry of PTRF in spleen tissue with PTRF antibody at 5 µg/ml.
  • IF - PTRF Antibody ASC11629
    Immunofluorescence of PTRF in human spleen tissue with PTRF antibody at 20 µg/ml.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q6NZI2
Other Accession NP_036364, 42734430
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 43 kDa
Application Notes PTRF antibody can be used for detection of PTRF by Western blot at 0.5 - 1 µg/mL.
Additional Information
Gene ID 284119
Target/Specificity PTRF; At least three isoforms of PTRF are known to exist; this antibody detects all three isoforms. It is predicted to not cross-react with other members of the cavin family.
Reconstitution & Storage PTRF antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsPTRF Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CAVIN1 (HGNC:9688)
Synonyms PTRF
Function Plays an important role in caveolae formation and organization. Essential for the formation of caveolae in all tissues (PubMed:18056712, PubMed:18191225, PubMed:19726876). Core component of the CAVIN complex which is essential for recruitment of the complex to the caveolae in presence of calveolin-1 (CAV1). Essential for normal oligomerization of CAV1. Promotes ribosomal transcriptional activity in response to metabolic challenges in the adipocytes and plays an important role in the formation of the ribosomal transcriptional loop. Dissociates transcription complexes paused by DNA-bound TTF1, thereby releasing both RNA polymerase I and pre-RNA from the template (By similarity).
Cellular Location Membrane, caveola. Cell membrane. Microsome Endoplasmic reticulum {ECO:0000250|UniProtKB:P85125}. Cytoplasm, cytosol. Mitochondrion Nucleus. Note=Translocates to the cytoplasm from the caveolae upon insulin stimulation (PubMed:17026959) Colocalizes with CAV1 in lipid rafts in adipocytes. Localizes in the caveolae in a caveolin-dependent manner (By similarity) {ECO:0000250|UniProtKB:O54724, ECO:0000269|PubMed:17026959}
Citations (0)

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PTRF Antibody: The polymerase I and transcript release factor (PTRF) enables the dissociation of paused ternary polymerase I transcription complexes from the 3' end of pre-rRNA transcripts, regulating rRNA transcription by promoting the dissociation of transcription complexes and the re-initiation of polymerase I on nascent rRNA transcripts. PTRF also localizes to caveolae at the plasma membrane and is thought to play a critical role in the formation of caveolae and the stabilization of caveolins, translocating from caveolae to the cytoplasm after insulin stimulation. PTRF is also thought to modify lipid metabolism and insulin-regulated gene expression. Mutations in this gene result in a disorder characterized by generalized lipodystrophy and muscular dystrophy.


Jansa P, Mason SW, Hoffmann-Rohrer U, et al. Cloning and functional characterization of PTRF, a novel protein which induces dissociation of paused ternary transcription complexes. EMBO J. 1998; 17:2855-64.
Vinten J, Johnsen AH, Roepstorff P, et al. Identification of a major protein on the cytosolic face of caveolae. Biochim. Biophys. Acta 2005; 1717:34-40.
Aboulaich N, Ortegren U, Vener AV, et al. Association and insulin regulated translocation of hormone-sensitive lipase with PTRF. Biochem. Biophys. Res. Commun. 2006; 350:657-61.
Aboulaich N, Chui PC, Asara JM, et al. Polymerase I and transcript release factor regulates lipolysis via a phosphorylation-dependent mechanism. Diabetes 2011; 60:757-65.

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$ 335.00
Cat# ASC11629
Availability: 5-7days
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