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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Nucleobindin-2 Antibody   

Nucleobindin-2 Antibody

  • WB - Nucleobindin-2 Antibody ASC11631
    Western blot analysis of Nucleobindin-2 in rat brain tissue lysate with Nucleobindin-2 antibody at (A) 0.5 and (B) 1 µg/mL.
  • IHC - Nucleobindin-2 Antibody ASC11631
    Immunohistochemistry of Nucleobindin-2 in rat brain tissue with Nucleobindin-2 antibody at 2.5 µg/ml.
  • IF - Nucleobindin-2 Antibody ASC11631
    Immunofluorescence of Nucleobindin-2 in rat brain tissue with Nucleobindin-2 antibody at 20 µg/ml.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P80303
Other Accession NP_005004, 4826870
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 46 kDa

Observed: 54 kDa
Application Notes Nucleobindin-2 Antibody can be used for detection of Nucleobindin-2 by Western blot starting at 0.5 µg/mL.
Additional Information
Gene ID 4925
Target/Specificity NUCB2; Nucleobindin-2 antibody is predicted to not cross-react with NUCB1.
Reconstitution & Storage Nucleobindin-2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsNucleobindin-2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NUCB2
Synonyms NEFA
Function Calcium-binding protein. May have a role in calcium homeostasis.
Cellular Location Golgi apparatus. Membrane; Peripheral membrane protein. Cytoplasm. Secreted. Endoplasmic reticulum. Nucleus envelope. Note=Golgi retention is mediated by its N-terminal region
Tissue Location Predominantly expressed in spleen, testis and normal stomach.
Research Areas
Citations (0)

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Nucleobindin-2 Antibody: NUCB2 was initially identified as calcium-binding protein EF hand motif-containing protein that could bind with Necdin, a growth suppressor expressed primarily in postmitotic neurons. NUC2 is a secreted protein that is cleaved into three major peptide products, Nesfatin-1, Nesfatin-2, and Nesfatin-3, of which Nesfatin-1 has been found to cause the suppression of food intake in a leptin-independent manner. Other studies have suggested that NUCB2/Nesfatin-1 may also play roles in energy homeostasis and closely related neuroendocrine functions.


Taniguchi N, Taniura H, Niinobe M, et al. The postmitotic growth suppressor necdin interacts with a calcium-binding protein (NEFA) in neuronal cytoplasm. J. Biol. Chem. 2000; 275:31674-85.
Oh IS, Shimizu H, Satoh T, et al. Identification of nesfatin-1 as a satiety molecule in the hypothalamus. Nature 2006; 443:709-12.
Garcia-Galiano D, Navarro VM, Gaytan F, et al. Expanding roles of NUCB2/nesfatin-1 in neuroendocrine regulation. J. Mol. Endocrin. 2010; 45:281-90.

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$ 335.00
Cat# ASC11631
Availability: 5-7days
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