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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   GBP5 Antibody   

GBP5 Antibody

  • WB - GBP5 Antibody ASC11651
    Western blot analysis of GBP5 in rat liver tissue lysate with GBP5 antibody at 1 µg/mL in (A) the absence and (B) the presence of blocking peptide.
  • IHC - GBP5 Antibody ASC11651
    Immunohistochemistry of GBP5 in human liver tissue with GBP5 antibody at 2.5 µg/ml.
  • IF - GBP5 Antibody ASC11651
    Immunofluorescence of GBP5 in human liver tissue with GBP5 antibody at 20 µg/ml.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q96PP8
Other Accession NP_443174, 16418425
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 64 kDa

Observed: 66 kDa
Application Notes GBP5 Antibody can be used for detection of GBP5 by Western blot at 1 µg/mL.
Additional Information
Gene ID 115362
Target/Specificity GBP5; GBP5 antibody is predicted to not cross-react with other GBP family members.
Reconstitution & Storage GBP5 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsGBP5 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GBP5
Function As an activator of NLRP3 inflammasome assembly, plays a role in innate immunity and inflammation. Promotes selective NLRP3 inflammasome assembly in response to microbial and soluble, but not crystalline, agents (PubMed:22461501). Hydrolyzes GTP, but in contrast to other family members, does not produce GMP (PubMed:20180847).
Cellular Location Cytoplasm. Golgi apparatus membrane; Lipid- anchor
Tissue Location Expressed in peripheral blood monocytes (at protein level).
Research Areas
Citations (0)

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GBP5 Antibody: The guanylate-binding proteins (GBPs) are a family of interferon-induced GTP-binding proteins function in innate immunity against microbial and viral pathogens. In humans, there are seven GBPs from hGBP1 to hGBP7. Human GBP1 and GBP2 have been shown to exhibit antiviral activity as well as being able to regulate the inhibition of proliferation and invasion of endothelial cells in response to interferon (IFN). GBP5 promotes selective NALP3 inflammasome responses to pathogenic bacteria and soluble but not crystalline inflammasome priming agents.


Vestal DJ. The guanylate-binding proteins (GBPs): proinflammatory cytokine-induced members of the dynamin superfamily with unique GTPase activity. J. Interferon Cytokine Res. 2005; 25:435-43.
Kresse A, Konermann C, Degrandi D, et al. Analyses of murine GBP homology clusters based on in silico, in vitro and in vivo studies. BMC Genomics 2008; 9:158.
Hammon M, Herrmann M, Bleiziffer O, et al. Role of guanylate binding protein-1 in vascular defects associated with chronic inflammatory diseases. J. Cell Mol. Med. 2011; 15:1582-92.
Shenoy AR, Wellington DA, Kumar P, et al. GBP5 promotes NLRP3 inflammasome assembly and immunity in mammals. Science 2012; 336:481-5.

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$ 335.00
Cat# ASC11651
Availability: 5-7days
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