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DDC Antibody

  • WB - DDC Antibody  ASC11687
    Western blot analysis of DDC in human lung tissue lysate with DDC antibody at 1 µg/ml.
  • IHC - DDC Antibody  ASC11687
    Immunohistochemistry of DDC in human lung tissue with DDC antibody at 2.5 µg/mL.
  • IF - DDC Antibody  ASC11687
    Immunofluorescence of DDC in human lung tissue with DDC antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P20711
Other Accession NP_000781, 4503281
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 53 kDa

Observed: 50 kDa
Application Notes DDC antibody can be used for detection of DDC by Western blot at 1 - 2 µg/ml.
Additional Information
Gene ID 1644
Target/Specificity DDC; DDC antibody is human, mouse and rat reactive.
Reconstitution & Storage DDC antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsDDC Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DDC
Synonyms AADC
Function Catalyzes the decarboxylation of L-3,4- dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.
Research Areas
Citations (0)

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DOPA decarboxylase (DDC) belongs to the group II decarboxylase family of proteins (1). It is an important protein in the catecholamine biosynthesis pathway. DDC catalyzes the second reaction in the biosynthesis of catecholamines, trace amines and serotonin (1,2). It can form a homodimer and is expressed in the central nervous system (2). DDC can be used as markers for dopaminergic, noradrenergic and serotonergic neurons in a variety of applications including depression, schizophrenia, Parkinson's disease, neuroendocrine tumors and drug abuse (3,4). Defects in DDC gene may cause the autosomal recessive disorder AADC deficiency (4).


Berry MD, Juorio AV, Li XM, et al. Aromatic L-amino acid decarboxylase: a neglected and misunderstood enzyme. Neurochem. Res. 1996; 21:1075-87.
Sumi-Ichinose C, Ichinose H, Takahashi E, et al. Molecular cloning of genomic DNA and chromosomal assignment of the gene for human aromatic L-amino acid decarboxylase, the enzyme for catecholamine and Serotonin biosynthesis. Biochemistry 1992; 31:2229-38.
Haycock JW, Becker L, Ang L, et al. Marked disparity between age-related changes in dopamine and other presynaptic dopaminergic markers in human striatum. J. Neurochem. 2003; 87:574-85.
Chang YT, Sharma R, Marsh JL, et al. Levodopa-responsive aromatic L-amino acid decarboxylase deficiency. Ann. Neurol. 2004; 55:435-8.

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$ 335.00
Cat# ASC11687
Availability: 5-7days
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