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TMEM107 Antibody

  • WB - TMEM107 Antibody  ASC11701
    Western blot analysis of TMEM107 in THP-1 cell lysate with TMEM107 antibody at 1 µg/ml in (A) the absence and (B) the presence of blocking peptide.
  • IHC - TMEM107 Antibody  ASC11701
    Immunohistochemistry of TMEM107 in human lymph node tissue with TMEM107 antibody at 5 µg/mL.
  • IF - TMEM107 Antibody  ASC11701
    Immunofluorescence of TMEM107 in human lymph node tissue with TMEM107 antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q6UX40
Other Accession NP_115730, 34101276
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 16 kDa

Observed: 19kDa
Application Notes TMEM107 antibody can be used for detection of TMEM107 by Western blot at 1 - 2 µg/ml.
Additional Information
Gene ID 84314
Target/Specificity TMEM107; TMEM107 antibody is human specific. At least two isoforms of TMEM107 are known to exist.
Reconstitution & Storage TMEM107antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsTMEM107 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TMEM107 (HGNC:28128)
Function Plays a role in cilia formation and embryonic patterning. Requires for normal Sonic hedgehog (Shh) signaling in the neural tube and acts in combination with GLI2 and GLI3 to pattern ventral and intermediate neuronal cell types (By similarity). During ciliogenesis regulates the ciliary transition zone localization of some MKS complex proteins (PubMed:26518474).
Cellular Location Membrane; Multi-pass membrane protein. Cell projection, cilium. Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme
Research Areas
Citations (0)

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Transmembrane protein 107 (TMEM 107) is critical for cilia formation and embryonic patterning (1). It is a 139 amino acid transmembrane protein encoded by a gene that maps to human chromosome 17 which is associated with two key tumor suppressor genes p53 and BRCA1 (1,2). TMEM107 is required for normal Sonic hedgehog (Shh) signaling in the neural tube and acts in combination with Gli2 and Gli3 to pattern ventral and intermediate neuronal cell types (1,3). TMEM107 is also a strong candidate gene for central areolar choroidal dystrophy (CACD) (1-3).


Christopher KJ, Wang B, Kong Y, et al. Forward genetics uncovers transmembrane protein 107 as a novel factor required for ciliogenesis and sonic hedgehog signaling. Dev. Biol. 2012; 368:382-92.
Clark HF, Gurney AL, Abaya E, et al. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Genome Res. 2003; 13:2265-70.
Ho KS and Scott MP. Sonic hedgehog in the nervous system: functions, modifications and mechanisms. Curr. Opin. Neurobiol. 2002; 12:57-63.

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$ 335.00
Cat# ASC11701
Availability: 5-7days
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