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IL-37 Antibody

  • WB - IL-37 Antibody  ASC11707
    Western blot analysis of IL-37 in human lung tissue lysate with IL-37 antibody at 1 µg/ml in (A) the presence and (B) the absence of blocking peptide.
  • IHC - IL-37 Antibody  ASC11707
    Immunohistochemistry of IL-12A in human kidney tissue with IL-12A antibody at 5 µg/mL.
  • IF - IL-37 Antibody  ASC11707
    Immunofluorescence of IL-12A in human kidney tissue with IL-12A antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9NZH6
Other Accession NP_055254, 20127524
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 24 kDa

Observed: 23kDa
Application Notes IL-37 antibody can be used for detection of IL-37 by Western blot at 1 - 2 µg/ml.
Additional Information
Gene ID 27178
Target/Specificity IL37; IL-37 antibody is human specific. Multiple isoforms of IL-37 are known to exist; this antibody will only detect the largest isoform. IL-37 antibody is predicted to not cross-react with IL-36.
Reconstitution & Storage IL-37 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsIL-37 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IL37
Synonyms FIL1Z, IL1F7, IL1H4, IL1RP1
Function Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation.
Cellular Location Cytoplasm, cytosol Nucleus. Secreted Note=Stimulation with IL1B leads to colocalization with SMAD3 mostly in perinuclear regions (PubMed:20935647). Only the CASP1- cleaved mature form translocates into the nucleus upon LPS stimulation (PubMed:18390730)
Tissue Location In general, low constitutive expression, if any, in healthy tissues; high expression in inflammatory counterparts, including in synovial tissues from individuals with active rheumatoid arthritis. Isoform A, isoform B and isoform C are expressed in testis, colon, placenta, lung and lymph node Isoform D and isoform E were found only in testis and bone marrow Whereas only isoform A is found in brain, only isoform B in kidney and only isoform C in heart.
Research Areas
Citations (0)

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Interleukin 37 (IL-37) is a member of the interleukin 1 cytokine family (reviewed in 1). It can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). IL-37 also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18 (1). IL-37 can also interact with Smad3 and expression of IL-37 in macrophages or epithelial cells resulted in near complete suppression of pro-inflammatory cytokines, suggesting that IL-37 may act as a natural suppressor of the innate inflammatory and immune responses (2,3).


Boraschi D, Lucchesi D, Hainzl S, et al. IL-37: a new anti-inflammatory cytokine of the IL-1 family. Eur. Cytokine Netw. 2011; 22:127-47.
Nold MF, Nold-Petry CA, Zepp JA, et al. Interleukin 37 is a fundamental inhibitor of innate immunity. Nat. Immunol. 2010; 11:1014-22.
Sakai N, Van Sweringen HL, Belizaire RM, et al. Interleukin-37 reduces liver inflammatory injury via effects on hepatocytes and non-parenchymal cells. J. Gastroenterol. Hepatol. 2012; 27:1609-16.

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$ 335.00
Cat# ASC11707
Availability: 5-7days
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