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Betatrophin Antibody

  • WB - Betatrophin Antibody ASC11741
    Western blot analysis of Betatrophin in rat liver tissue lysate with Betatrophin antibody at (A) 1 and (B) 2 µg/ml.
  • IHC - Betatrophin Antibody ASC11741
    Immunohistochemistry of Betatrophin in mouse liver tissue with Betatrophin antibody at 5 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q6UXH0
Other Accession NP_061157, 291219911
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 22 kDa

Observed: 22 kDa
Application Notes Betatrophin antibody can be used for detection of Betatrophin by Western blot at 1 - 2 µg/ml. Antibody can also be used for Immunohistochemistry starting at 5 µg/mL.
Additional Information
Gene ID 55908
Target/Specificity C19orf80; Betatrophin antibody is human, mouse and rat reactive. At least three isoforms of Betatrophin are known to exist; this antibody will detect the two largest isoforms.
Reconstitution & Storage Betatrophin antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsBetatrophin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ANGPTL8 (HGNC:24933)
Function Hormone that acts as a blood lipid regulator by regulating serum triglyceride levels (PubMed:22569073, PubMed:22809513, PubMed:23150577). May be involved in the metabolic transition between fasting and refeeding: required to direct fatty acids to adipose tissue for storage in the fed state (By similarity).
Cellular Location Secreted
Tissue Location Predominantly expressed in liver. Also expressed in adipose tissues.
Research Areas
Citations (0)

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The Betatrophin protein, also known as the hepatocellular carcinoma-associated protein TD26, is an adipocyte- and liver-enriched insulin targeted gene that is thought to play a role in lipid metabolism be regulating serum triglyceride levels (1,2). Betatrophin is closely related to the angiopoietin-like (ANGPTL) protein family. Betatrophin mRNA increases in the cold environment and after treatment with a high-fat diet, while its mRNA levels decrease in response to fasting, suggesting that it may play a role in mediating thermogenesis and energy homeostasis (3).


Ren G, Kim JY, and Smas CM. Identification of RIFL, a novel adipocyte-enriched insulin target gene with a role in lipid metabolism. Am. J. Endocrinol. Metab. 2012; 303:E334-51.
Zhang R. Lipasin, a novel nutritionally-regulated liver-enriched factor that regulates serum triglyceride levels. Biochem. Biophys. Res. Commun. 2012; 424:786-92.
Fu Z, Yao F, Abou-Samra AB, et al. Lipasin, thermoregulated in brown fat, is a novel but atypical member of the angiopoietin-like protein family. Biochem. Biophys. Res. Commun. 2013; 430:1126-31.

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$ 335.00
Cat# ASC11741
Availability: 5-7days
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