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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   LAMTOR2 Antibody   

LAMTOR2 Antibody

  • WB - LAMTOR2 Antibody ASC11768
    Western blot analysis of LAMTOR2 in HepG2 cell lysate with LAMTOR2 antibody at 1 µg/ml.
  • IHC - LAMTOR2 Antibody ASC11768
    Immunohistochemistry of LAMTOR2 in human spleen tissue with LAMTOR2 antibody at 5 µg/mL.
  • IF - LAMTOR2 Antibody ASC11768
    Immunofluorescence of LAMTOR2 in human spleen tissue with LAMTOR2 antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9Y2Q5
Other Accession NP_054736, 7661728
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 14 kDa

Observed: 16 kDa
Application Notes LAMTOR2 antibody can be used for detection of LAMTOR2 by Western blot at 1 - 2 µg/ml. Antibody can also be used for Immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 28956
Target/Specificity LAMTOR2; LAMTOR2 antibody is human, mouse and rat reactive. At least two isoforms of LAMTOR2 are known to exist; this antibody will detect both isoforms. LAMTOR2 antibody is predicted to not cross-react with other LAMTOR family proteins.
Reconstitution & Storage LAMTOR2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsLAMTOR2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.
Cellular Location Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side
Research Areas
Citations (0)

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The late endosomal/lysosomal adaptor MAPK and MTOR activator 2 (LAMTOR2) protein belongs to the LAMTOR family of proteins, and together with LAMTOR3 and the MAPK1 and ERK kinase 1 (MEK1) localizes to late endosomes where it is required for the efficient activation of ERK signaling (1,2). This complex is involved in the regulation of late endosomal traffic and cellular proliferation (3) and plays a role in cellular host defense against Salmonella infection (4).


Wunderlich W, Fialka I, Teis D, et al. A novel 14-kilodalton protein interacts with the mitogen-activated protein kinase scaffold MP1 on a late endosomal/lysosomal compartment. J. Cell Biol. 2001; 152:765-76.
Teis D, Wunderlich W, and Huber LA. Localization of the MP1-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction. Dev. Cell 2002; 3:803-14.
Teis D, Taub N, Kurzbauer R, et al. p14-MP1-MEK1 signaling regulates endosomal traffic and cellular proliferation during tissue homeostasis. J. Cell Biol. 2006; 175:861-8.
Taub N, Nairz M, Hilber D, et al. The late endosomal adaptor p14 is a macrophage host-defense factor against Salmonella infection. J. Cell Sci. 2012; 125:2698-708.

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$ 335.00
Cat# ASC11768
Availability: 5-7days
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