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ATMIN Antibody

  • WB - ATMIN Antibody ASC11793
    Western blot analysis of ATMIN in 293 cell lysate with ATMIN antibody at (A) 1 and (B) 2 µg/ml.
  • ICC - ATMIN Antibody ASC11793
    Immunocytochemistry of ATMIN in A431 cells with ATMIN antibody at 5 µg/mL.
  • IF - ATMIN Antibody ASC11793
    Immunofluorescence of ATMIN in A431 cells with ATMIN antibody at 2.5 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O43313
Other Accession NP_056066, 54792092
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 73, 79, 91 kDa

Observed: 72 kDa
Application Notes ATMIN antibody can be used for detection of ATMIN by Western blot at 1 - 2 µg/ml. Antibody can also be used for Immunocytochemistry at 5 µg/mL. For Immunoflorescence start at 2.5 µg/mL.
Additional Information
Gene ID 23300
Target/Specificity ATMIN; ATMIN antibody is human, mouse and rat reactive. At least three isoforms of ATMIN are known to exist.
Reconstitution & Storage ATMIN antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsATMIN Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms KIAA0431, ZNF822
Function Transcription factor. Plays a crucial role in cell survival and RAD51 foci formation in response to methylating DNA damage. Involved in regulating the activity of ATM in the absence of DNA damage. May play a role in stabilizing ATM. Binds to the DYNLL1 promoter and activates its transcription.
Cellular Location Nucleus. Note=Nuclear, in discrete foci during G1 phase
Tissue Location Ubiquitously expressed in normal tissues and cancer cell lines with highest levels in placenta and skeletal muscle.
Citations (0)

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The ATM/ATR-substrate CHK2-interacting zinc finger protein (ATMIN), also known as ASCIZ, forms DNA damage-induced nuclear foci that contain the DNA repair protein Rad51 (1). ATMIN is also thought to be involved in embryonic development, as an absence of ATMIN causes late-embryonic lethality in mice with a range of organ development defects (2). It also activates the transcription DYNLL1, a light chain of the dynein motor complex and sequence-specific regulator of protein dimerization of numerous targets. DYNLL1 can bind to and inhibit the transcription activation domain of ATMIN, forming a simple dynamic feedback loop for DYNLL1 expression (3).


McNees CJ, Conlan LA, Tenis N, et al. ASCIZ regulates lesion-specific Rad51 focus formation and apoptosis after methylating DNA damage. EMBO J. 2005; 24:2447-57.
Jurado S, Smyth I, van Denderen B, et al. Dual functions of ASCIZ in the DNA base damage response and pulmonary organogenesis. PLoS Genet. 2010; 6:e1001170.
Jurado S, Conlan LA, Baker EK, et al. ATM substrate Chk2-interating Zn2+ finger (ASCIZ) is a bi-functional transcriptional activator and feedback sensor in the regulation of Dynein Light Chain (DYNLL1) expression. J. Biol. Chem. 2012; 287:3156-64.

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$ 335.00
Cat# ASC11793
Availability: 5-7days
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