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TICRR Antibody

  • WB - TICRR Antibody ASC11813
    Western blot analysis of TICRR in human small intestine tissue lysate with TICRR antibody at 1 µg/ml.
  • IHC - TICRR Antibody ASC11813
    Immunohistochemistry of TICRR in human small intestine tissue with TICRR antibody at 5 µg/mL.
  • IF - TICRR Antibody ASC11813
    Immunofluorescence of TICRR in human small intestine tissue with TICRR antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q7Z2Z1
Other Accession NP_689472, 118421085
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 210 kDa

Observed: 220 kDa
Application Notes TICRR antibody can be used for detection of TICRR by Western blot at 1 - 2 µg/ml. Antibody can also be used for Immunohistochemistry at 5 µg/mL. For Immunoflorescence start at 20 µg/mL.
Additional Information
Gene ID 90381
Target/Specificity TICRR; TICRR antibody is human specific. At least two isoforms of TICRR are known to exist.
Reconstitution & Storage TICRR antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsTICRR Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms C15orf42
Function Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre- initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation.
Cellular Location Nucleus. Note=Associates with chromatin
Citations (0)

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TopBP1-interacting checkpoint and replication regulator, Treslin,chromosome 15 open reading frame 42, C15ORF42


Sansam CL, Cruz NM, Danielian PS, et al. A vertebrate gene, ticrr, is an essential checkpoint and replication regulator. Genes Dev. 2010; 24:183-94.
Kumagai A, Shevchenko A, Shevchenko A, et al. Direct regulation of Treslin by cyclin-dependent kinase is essential for the onset of DNA replication. J. Cell Biol. 2011;193:995-1007.
Kumagai A, Shevchenko A, Shevchenko A, et al. Treslin collaborates with TopBP1 in triggering the initiation of DNA replication. Cell 2010; 140:349-59.
Mueller AC, Keaton MA, and Dutta A. DNA replication: mammalian Treslin-TopBP1 interaction mirrors yeast Sld3-Dpb11. Curr. Biol. 2011; 21:R638-40.

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$ 335.00
Cat# ASC11813
Availability: 5-7days
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