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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   XKR8 Antibody   

XKR8 Antibody

  • WB - XKR8 Antibody ASC11851
    Western blot analysis of XKR8 in human stomach tissue lysate with XKR8 antibody at 1 µg/ml.
  • IHC - XKR8 Antibody ASC11851
    Immunohistochemistry of XKR8 in human stomach tissue with XKR8 antibody at 5 µg/ml.
  • IF - XKR8 Antibody ASC11851
    Immunofluorescence of XKR8 in human stomach tissue with XKR8 antibody at 20 µg/ml.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9H6D3
Other Accession NP_060523, 24431977
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 43 kDa

Observed: 47 kDa
Application Notes XKR8 antibody can be used for detection of XKR8 by Western blot at 1 - 2 µg/ml. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 55113
Target/Specificity XKR8; XKR8 antibody is human reactive. At least two isoforms are known to exist; this antibody will detect both isoforms.
Reconstitution & Storage XKR8 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsXKR8 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name XKR8
Synonyms XRG8
Function Promotes phosphatidylserine exposure on apoptotic cell surface, possibly by mediating phospholipid scrambling. Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment. Has no effect on calcium-induced exposure of phosphatidylserine. Activated upon caspase cleavage, suggesting that it does not act prior the onset of apoptosis.
Cellular Location Cell membrane; Multi-pass membrane protein
Research Areas
Citations (0)

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The XK Kell blood group complex subunit-related family member 8 (XKR8) is a member of a family of proteins that promote the phagocytosis of dying cells by altering the phospholipid distribution of the plasma membrane (1). XKR8 is thought to be a “scramblase”, an enzyme that eliminates the asymmetry of phospholipid distribution in the plasma membrane. In apoptotic cells, XKR8 promotes the cell-surface exposure of phosphatidylserine (PtdSer) which serves as a signal for phagocytosis (1,2).


Suzuki J, Denning DP, Imanishi E, et al. Xk-related protein 8 and CED-8 promote phosphatidylserine exposure in apoptotic cells. Science 2013; 341:403-6.
Wang X, Wu YC, Fadok VA, et al. Cell corpse engulfment mediated by C. elegans phosphatidylserine receptor through CED-5 and CED-12. Science 2003; 302:1563-6.

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$ 335.00
Cat# ASC11851
Availability: 5-7days
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