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PTPN5 Antibody

  • WB - PTPN5 Antibody ASC11866
    Western blot analysis of PTPN5 in Jurkat cell lysate with PTPN5 antibody at (A) 1 and (B) 2 µg/ml.
  • IHC - PTPN5 Antibody ASC11866
    Immunohistochemistry of PTPN5 in mouse brain tissue with PTPN5 antibody at 5 µg/ml.
  • IF - PTPN5 Antibody ASC11866
    Immunofluorescence of PTPN5 in mouse brain tissue with PTPN5 antibody at 20 µg/ml.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q86TL6
Other Accession NP_008837, 90652859
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 62 kDa

Observed: 60 kDa
Application Notes PTPN5 antibody can be used for detection of PTPN5 by Western blot at 1 - 2 µg/ml. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 84867
Target/Specificity PTPN5; PTPN5 antibody is human and mouse reactive.
Reconstitution & Storage PTPN5 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsPTPN5 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Citations (0)

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The protein tyrosine phosphatase PTPN5, also known as Striatal enriched phosphatase (STEP), is involved in the regulation of synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors (1). It is expressed in dopaminoceptive neurons of the central nervous system and multiple forms of PTPN5 show differential enrichment in adult brain regions (2). NMDA-mediated activation of PTPN5 is an important mechanism for regulation of Erk activity in neurons (3). Furthermore, PTPN5 is involved in the regulation of both NMDAR and AMPAR trafficking (4,5). PTPN5 may play a role in Alzheimer's disease (1).


Braithwaite SP, Paul S, Nairn AC, et al. Synaptic plasticity: one STEP at a time. Trends Neurosci. 2006; 29:452-8.
Paul S, Snyder GL, Yokakura H, et al. The Dopamine/D1 receptor mediates the phosphorylation and inactivation of the protein tyrosine phosphatase STEP via a PKA-dependent pathway. J. Neurosci. 2000; 20:5630-8.
Paul S, Nairn AC, Wang P, et al. NMDA-mediated activation of the tyrosine phosphatase STEP regulates the duration of ERK signaling. Nat. Neurosci. 2003; 6:34-42.
Braithwaite SP, Adkisson M, Leung J, et al. Regulation of NMDA receptor trafficking and function by striatal-enriched tyrosine phosphatase (STEP). Eur. J. Neurosci. 2006; 23:2847-56.

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$ 335.00
Cat# ASC11866
Availability: 5-7days
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