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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   SLC1A7 Antibody   

SLC1A7 Antibody

  • WB - SLC1A7 Antibody ASC11888
    Western blot analysis of SLC1A7 in C2C12 cell lysate with SLC1A7 antibody at 1 µg/ml in (A) the absence and (B) the presence of blocking peptide.
  • IHC - SLC1A7 Antibody ASC11888
    Immunohistochemistry of SLC1A7 in mouse kidney tissue with SLC1A7 antibody at 5 µg/ml.
  • IF - SLC1A7 Antibody ASC11888
    Immunofluorescence of SLC1A7 in mouse kidney tissue with SLC1A7 antibody at 20 µg/ml.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O00341
Other Accession NP_001274524, 567316146
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 17, 52, 62, 68 kDa

Observed: 52 kDa
Application Notes SLC1A7 antibody can be used for detection of SLC1A7 by Western blot at 1 - 2 µg/ml. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 6512
Target/Specificity SLC1A7; SLC1A7 antibody is human and mouse reactive. Multiple isoforms of SLC1A7 are known to exist.
Reconstitution & Storage SLC1A7 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsSLC1A7 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SLC1A7
Synonyms EAAT5
Function Transports L-glutamate; the L-glutamate uptake is sodium- and voltage-dependent and chloride-independent. Its associated chloride conductance may participate in visual processing.
Cellular Location Membrane; Multi-pass membrane protein.
Tissue Location Expressed primarily in retina. Detectable in liver, heart, muscle and brain
Research Areas
Citations (0)

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The solute carrier family 1 member 7 (SLC1A7) protein was initially identified as a glutamate transporter coupled to a chloride conductance that is expressed primarily in the retina (1). More recent evidence indicates that is it widely expressed in peripheral tissues, also (2). Experiments have shown that SLC1A7 functions as a low-affinity/low-capacity glutamate transport, with an anion channel optimized for anion conductance in the negative voltage range (3). In the retina, SLC1A7 co-localizes with the serum and glucocorticoid dependent kinase SGK1, and its cell surface expression and activity is regulated SGK1 and its isoform SGK3 (4).


Arriza JL, Eliasof S, Kavanaugh MP, et al. Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance. Proc. Natl. Acad. Sci. USA 1997; 94:4155-60.
Lee A, Anderson AR, Stevens M, et al. Excitatory amino acid transporter 5 is widely expressed in peripheral tissues. Eur. J. Histochem. 2013; 57:e11.
Schneider N, Cordeiro S, Machtens JP, et al. Functional properties of the retinal glutamate transporters GLT-1c and EAAT5. J. Biol. Chem. 2014; 289:1815-24.
Boehmer C, Rajamanickam J, Schniepp R, et al. Regulation of the excitatory amino acid transporter EAAT5 by the serum and glucocorticoid dependent kinases SGK1 and SGK3. Biochem. Biophys. Res. Commun. 2005; 329:738-42.

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$ 335.00
Cat# ASC11888
Availability: 5-7days
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