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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   MYH3 Antibody   

MYH3 Antibody

  • WB - MYH3 Antibody ASC11890
    Western blot analysis of MYH3 in Jurkat cell lysate with MYH3 antibody at 1 µg/ml.
  • IHC - MYH3 Antibody ASC11890
    Immunohistochemistry of MYH3 in mouse skeletal muscle tissue with MYH3 antibody at 5 µg/ml.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P11055
Other Accession NP_002461, 98986453
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 213 kDa

Observed: 240 kDa
Application Notes MYH3 antibody can be used for detection of MYH3 by Western blot at 1 - 2 µg/ml. Antibody can also be used for immunohistochemistry starting at 5 µg/mL.
Additional Information
Gene ID 4621
Target/Specificity MYH3; MYH3 antibody is human, mouse and rat reactive. MYH3 antibody is predicted to not cross-react with other members of the myosin heavy chain family.
Reconstitution & Storage MYH3 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsMYH3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MYH3
Function Muscle contraction.
Cellular Location Cytoplasm, myofibril. Note=Thick filaments of the myofibrils
Tissue Location Expressed in fetal bone, thymus, placenta, heart, brain, and liver.
Research Areas
Citations (0)

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Myosins are actin-based motor proteins that function in the generation of mechanical force in eukaryotic cells (1). MYH3 (myosin, heavy chain, skeletal muscle, embryonic) plays a significant role in skeletal muscle development (2) and is also essential for the proper morphology and function of the developing heart (3). Mutations in this gene have been associated with Freeman-Sheldon syndrome and Sheldon-Hall syndrome (4).


Yu H, Waddell JN, Kuang S, et al. Park7 expression influences myotube size and myosin expression in muscle. PLoS One 2014; 9:e92030.
Lagrutta AA, McCarthy JG, Scherczinger CA, et al. Identification and developmental expression of a novel embryonic myosin heavy-chain gene in chicken. DNA 1989; 8:39-50.
Rutland CS, Polo-Parada L, Ehler E, et al. Knockdown of embryonic myosin heavy chain reveals an essential role in the morphology and function of the developing heart. Development 2011; 138:3955-66.
Toydemir RM, Rutherford A, Whitby FG, et al. Mutations in embryonic myosin heavy chain (MYH3) cause Freeman-Sheldon syndrome and Sheldon-Hall syndrome. Nat. Genet. 2006; 38:561-5.

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$ 335.00
Cat# ASC11890
Availability: 5-7days
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