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ADORA2B Antibody

  • WB - ADORA2B Antibody ASC11898
    Western blot analysis of ADORA2B in mouse colon tissue lysate with ADORA2B antibody at (A) 0.5 and (B) 1 µg/ml.
  • IHC - ADORA2B Antibody ASC11898
    Immunohistochemistry of ADORA2B in rat colon tissue with ADORA2B antibody at 5 µg/mL.
  • IF - ADORA2B Antibody ASC11898
    Immunofluorescence of ADORA2B in rat colon tissue with ADORA2B antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P29275
Other Accession NP_000667, 4501951
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 37 kDa

Observed: 41 kDa
Application Notes ADORA2B antibody can be used for detection of ADORA2B by Western blot at 0.5 - 1 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 136
Target/Specificity ADORA2B; ADORA2B antibody is human, mouse and rat reactive. At least two isoforms of ADORA2B are known to exist; this antibody will detect both isoforms. ADORA2B antibody is predicted to not cross-react with ADORA2A.
Reconstitution & Storage ADORA2B antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsADORA2B Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
Cellular Location Cell membrane; Multi-pass membrane protein.
Research Areas
Citations (0)

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The adenosine receptor ADORA2B is a member of the G protein-coupled receptor superfamily and is an integral membrane protein that stimulates adenylate cyclase activity in the presence of adenosine (1,2). Extracellular adenosine triggers a potent anti-inflammatory response that is mediated in part by ADORA2B including the stimulation of IL-10 production (3-5). Activation of ADORA2B can also enhance the abundance of regulatory T cells (Tregs), a class of cells that work to constrain inflammation (6).


Pierce KD, Furlong TJ, Selbie LA, et al. Molecular cloning and expression of an adenosine A2b receptor from human brain. Biochem. Biophys. Res. Commun. 1992; 187:86-93.
Thimm D, Schiedel AC, Sherbiny FF, et al. Ligand-specific binding and activation of the human adenosine A(2B) receptor. Biochem. 2013; 52:726-40.
Blackburn MR, Vance CO, Morschl E, et al. Adenosine receptors and inflammation. Handb. Exp. Pharmacol. 2009; 215-69.
Grenz A, Homann D, Eltzschig HK. Extracellular adenosine: a safety signal that dampens hypoxia-induced inflammation during ischemia. Antioxid. Redox Signal. 2011; 15:2221-34.

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$ 335.00
Cat# ASC11898
Availability: 5-7days
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