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>   home   >   Products   >   Primary Antibodies   >   Cardiovascular   >   HOPX Antibody   

HOPX Antibody

  • WB - HOPX Antibody ASC11910
    Western blot analysis of HOPX in human brain tissue lysate with HOPX antibody at (A) 1 and (B) 2 µg/ml.
  • IHC - HOPX Antibody ASC11910
    Immunohistochemistry of HOPX in human heart tissue with HOPX antibody at 5 µg/mL.
  • IF - HOPX Antibody ASC11910
    Immunofluorescence of HOPX in human heart tissue with HOPX antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9BPY8
Other Accession NP_001138932, 224451025
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 12 kDa

Observed: 183 kDa
Application Notes HOPX antibody can be used for detection of HOPX by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 84525
Target/Specificity HOPX; HOPX antibody is human specific. At least three isoforms of HOPX are known to exist; this antibody will detect all three isoforms.
Reconstitution & Storage HOPX antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsHOPX Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms HOD, HOP, LAGY, NECC1, OB1
Function Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy (By similarity). May act as a tumor suppressor. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein refolding (PubMed:27708256).
Cellular Location Nucleus {ECO:0000250|UniProtKB:Q8R1H0}. Cytoplasm {ECO:0000250|UniProtKB:Q8R1H0}
Tissue Location Widely expressed. Expressed in the heart, brain, placenta, lung, skeletal and smooth muscles, uterus, urinary bladder, kidney and spleen. Down-regulated in some types of cancer such as lung cancer, choriocarcinoma, head and neck squamous cell carcinoma and oral squamous cell carcinoma EMBL; AF492675; AAM46827.1; -; mRNA EMBL; AF492676; AAM46828.1; -; mRNA EMBL; AF492677; AAM46829.1; -; mRNA EMBL; AF492678; AAM46830.1; -; mRNA EMBL; AF492679; AAM46831.1; -; mRNA EMBL; AF492680; AAM46832.1; -; mRNA EMBL; AF492681; AAM46833.1; -; mRNA EMBL; AB059408; BAB40926.1; -; mRNA EMBL; AB059409; BAB40927.1; -; mRNA EMBL; AB059410; BAB40928.1; -; mRNA EMBL; AF454763; AAL56613.1; -; mRNA EMBL; AK289707; BAF82396.1; -; mRNA EMBL; AC108215; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; BC014225; AAH14225.1; -; mRNA CCDS; CCDS3507.1; -. [Q9BPY8-1] CCDS; CCDS47062.1; -. [Q9BPY8-3] CCDS; CCDS54767.1; -. [Q9BPY8-4] RefSeq; NP_001138931.1; NM_001145459.1. [Q9BPY8-1] RefSeq; NP_001138932.1; NM_001145460.1. [Q9BPY8-4] RefSeq; NP_115884.4; NM_032495.5. [Q9BPY8-3] RefSeq; NP_631957.1; NM_139211.4. [Q9BPY8-1] RefSeq; NP_631958.1; NM_139212.3. [Q9BPY8-1] RefSeq; XP_016864218.1; XM_017008729.1 RefSeq; XP_016864219.1; XM_017008730.1. [Q9BPY8-1] RefSeq; XP_016864220.1; XM_017008731.1. [Q9BPY8-1] RefSeq; XP_016864221.1; XM_017008732.1. [Q9BPY8-1] RefSeq; XP_016864222.1; XM_017008733.1. [Q9BPY8-1] RefSeq; XP_016864223.1; XM_017008734.1. [Q9BPY8-1] UniGene; Hs.619396; - ProteinModelPortal; Q9BPY8; - SMR; Q9BPY8; - BioGrid; 124117; 11 IntAct; Q9BPY8; 2 STRING; 9606.ENSP00000450527; - iPTMnet; Q9BPY8; - PhosphoSitePlus; Q9BPY8; - BioMuta; HOPX; - DMDM; 60392394; - PaxDb; Q9BPY8; - PeptideAtlas; Q9BPY8; - PRIDE; Q9BPY8; - ProteomicsDB; 78595; - ProteomicsDB; 78596; -. [Q9BPY8-2] DNASU; 84525; - Ensembl; ENST00000317745; ENSP00000315198; ENSG00000171476. [Q9BPY8-1] Ensembl; ENST00000337881; ENSP00000337330; ENSG00000171476. [Q9BPY8-1] Ensembl; ENST00000381255; ENSP00000370654; ENSG00000171476. [Q9BPY8-1] Ensembl; ENST00000381260; ENSP00000370659; ENSG00000171476. [Q9BPY8-2] Ensembl; ENST00000420433; ENSP00000396275; ENSG00000171476. [Q9BPY8-3] Ensembl; ENST00000503639; ENSP00000424101; ENSG00000171476. [Q9BPY8-1] Ensembl; ENST00000508121; ENSP00000422175; ENSG00000171476. [Q9BPY8-1] Ensembl; ENST00000553379; ENSP00000452340; ENSG00000171476. [Q9BPY8-1] Ensembl; ENST00000554144; ENSP00000450527; ENSG00000171476. [Q9BPY8-4] Ensembl; ENST00000555760; ENSP00000452098; ENSG00000171476. [Q9BPY8-1] Ensembl; ENST00000556376; ENSP00000451794; ENSG00000171476. [Q9BPY8-1] Ensembl; ENST00000556614; ENSP00000452003; ENSG00000171476. [Q9BPY8-1] GeneID; 84525; - KEGG; hsa:84525; - UCSC; uc003hbz.3; human. [Q9BPY8-1] CTD; 84525; - DisGeNET; 84525; - EuPathDB; HostDB:ENSG00000171476.21; - GeneCards; HOPX; - HGNC; HGNC:24961; HOPX HPA; CAB018632; - HPA; HPA030180; - MIM; 607275; gene neXtProt; NX_Q9BPY8; - OpenTargets; ENSG00000171476; - PharmGKB; PA162391564; - eggNOG; KOG0490; Eukaryota eggNOG; ENOG410YIJ3; LUCA GeneTree; ENSGT00390000017143; - HOGENOM; HOG000112932; - HOVERGEN; HBG051921; - InParanoid; Q9BPY8; - OMA; KVSKHPD; - OrthoDB; EOG091G1BXE; - PhylomeDB; Q9BPY8; - SIGNOR; Q9BPY8; - ChiTaRS; HOPX; human GeneWiki; HOPX; - GenomeRNAi; 84525; - PRO; PR:Q9BPY8; - Proteomes; UP000005640; Chromosome 4 Bgee; ENSG00000171476; - CleanEx; HS_HOPX; - Genevisible; Q9BPY8; HS GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell GO; GO:0005634; C:nucleus; IDA:MGI GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW GO; GO:0000981; F:RNA polymerase II transcription factor activity, sequence-specific DNA binding; ISA:NTNU_SB GO; GO:0051131; P:chaperone-mediated protein complex assembly; IDA:CAFA GO; GO:0045596; P:negative regulation of cell differentiation; IDA:MGI GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW GO; GO:0001829; P:trophectodermal cell differentiation; IDA:MGI CDD; cd00086; homeodomain; 1 InterPro; IPR009057; Homeobox-like_sf InterPro; IPR001356; Homeobox_dom InterPro; IPR039162; HOPX PANTHER; PTHR21408; PTHR21408; 1 Pfam; PF00046; Homeobox; 1 SMART; SM00389; HOX; 1 SUPFAM; SSF46689; SSF46689; 1 PROSITE; PS50071; HOMEOBOX_2; 1 1: Evidence at protein level; Alternative splicing; Complete proteome; Cytoplasm; Developmental protein; Homeobox; Nucleus; Proto-oncogene; Reference proteome; Repressor; Transcription; Transcription regulation CHAIN 1 73 Homeodomain-only protein /FTId=PRO_0000049129 DNA_BIND 3 62 Homeobox; atypical. {ECO:0000255|PROSITE- ProRule:PRU00108} VAR_SEQ 1 1 M -> MLIFLGCYRRRLEERAGTM (in isoform 3 and isoform 4). /FTId=VSP_047290 VAR_SEQ 49 73 KWFKQRLAKWRRSEGLPSECRSVTD -> GSDLISRSKIWH PESSPQREGYPHDSLPCLAFDYFSLLPPQCKEMV (in isoform 2 and isoform 4) /FTId=VSP_012659 CONFLICT 72 72 T -> I (in Ref. 6; AAH14225) SEQUENCE 73 AA; 8260 MW; CE65E4D2A8972022 CRC64; MSAETASGPT EDQVEILEYN FNKVDKHPDS TTLCLIAAEA GLSEEETQKW FKQRLAKWRR SEGLPSECRS VTD
Research Areas
Citations (0)

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HOPX is a small homeodomain protein that lacks normally conserved residues required for DNA binding (1). It is thought to act downstream of NKX2-5 and modulates serum response factor (SRF)-dependent cardiac-specific gene expression and cardiac development (1). HOPX also acts a tumor suppressor gene in multiple tumors and cancer cell lines (2,3). HOPX has been reported to regulate the proliferation/differentiation homeostasis in different cell types, including keratinocytes (4).


Chen F, Kook H, Milewski R, et al. Hop is an unusual homeobox gene that modulates cardiac development. Cell 2002; 110:713-23.
Asanoma K, Matsuda T, Kondo H, et al. NECC1, a candidate choriocarcinoma suppressor gene that encodes a homeodomain consensus motif. Genomics 2003; 81:15-25.
Katoh H, Yamashita K, Waraya M, et al. Epigenetic silencing of HOPX promotes cancer progression in colorectal cancer. Neoplasia 2012; 14:559-71.
Obarzanek-Fojt M, Favre B, Kypriotou M, et al. Homeodomain-only protein HOP is a novel modulator of late differentiation in keratinocytes. Eur. J. Cell Biol. 2011; 90:279-90.

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$ 335.00
Cat# ASC11910
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