|Application ||WB, E|
|Other Accession||4502693, NP_001760, 928|
|Calculated MW||25416 Da|
|Application Notes||CD9 antibody can be used for Western blot at 1 - 2 µg/mL.|
|Other Names||CD9 Antibody: CD9 molecule, MIC3, MRP-1, BTCC-1, DRAP-27, TSPAN29, TSPAN-29|
|Precautions||CD9 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell adhesion, cell motility and tumor metastasis. Required for sperm-egg fusion.|
|Cellular Location||Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein|
|Tissue Location||Detected in platelets (at protein level). Expressed by a variety of hematopoietic and epithelial cells|
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Provided below are standard protocols that you may find useful for product applications.
CD9 Antibody: CD9 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Like other tetraspanins, CD9 is a cell surface glycoproteins play a role in many cellular processes including differentiation, adhesion, and signal transduction (1). CD9 expression plays a critical role in the suppression of cancer cell motility and metastasis. In one study, the knockdown of CD9 expression suppressed the metastatic capacity of human breast cancer cells (2), while other results have shown the opposite effect, suggesting that different proteins associated with CD9 account for its abilities to promote or suppress metastasis (3).
Murayama Y, Oritani K, and Tsutsui S. Novel CD9-targeted therapies in gastric cancer. World J. Gastroenterol. 2015; 21:3206-13.;Rappa G, Green TM, Karbanova J, Corbeil D, et al. Tetraspanin CD9 determines invasiveness and tumorigenicity of human breast cancer cells. Oncotarget 2015; 6:7970-91.;Zoller M. Tetraspanins: push and pull in suppressing and promoting metastasis. Nat. Rev. Cancer 2009; 9:40-55.;
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