ALG6 Antibody (monoclonal) (M09)
Mouse monoclonal antibody raised against a partial recombinant ALG6.
|Application ||WB, IF|
|Calculated MW||58121 Da|
|Other Names||Dolichyl pyrophosphate Man9GlcNAc2 alpha-1, 3-glucosyltransferase, Asparagine-linked glycosylation protein 6 homolog, Dol-P-Glc:Man(9)GlcNAc(2)-PP-Dol alpha-1, 3-glucosyltransferase, Dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase, ALG6|
|Target/Specificity||ALG6 (NP_037471, 25 a.a. ~ 114 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||ALG6 Antibody (monoclonal) (M09) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the ALG6/ALG8 glucosyltransferase family. The encoded protein catalyzes the addition of the first glucose residue to the growing lipid-linked oligosaccharide precursor of N-linked glycosylation. Mutations in this gene are associated with congenital disorders of glycosylation type Ic.
The DNA sequence and biological annotation of human chromosome 1. Gregory SG, et al. Nature, 2006 May 18. PMID 16710414.Congenital disorder of glycosylation Ic due to a de novo deletion and an hALG-6 mutation. Eklund EA, et al. Biochem Biophys Res Commun, 2006 Jan 20. PMID 16321363.The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039.Identification of a frequent variant in ALG6, the cause of Congenital Disorder of Glycosylation-Ic. Westphal V, et al. Hum Mutat, 2003 Nov. PMID 14517965.
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