ARRB2 Antibody (monoclonal) (M06)
Mouse monoclonal antibody raised against a partial recombinant ARRB2.
|Application ||WB, IF, E|
|Calculated MW||46106 Da|
|Other Names||Beta-arrestin-2, Arrestin beta-2, ARRB2, ARB2, ARR2|
|Target/Specificity||ARRB2 (AAH07427, 300 a.a. ~ 409 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||ARRB2 Antibody (monoclonal) (M06) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.
beta-Arrestin2 influences the response to methadone in opioid-dependent patients. Oneda B, et al. Pharmacogenomics J, 2010 Jun 1. PMID 20514076.Beta-arrestin 2 regulates Toll-like receptor 4-mediated apoptotic signalling through glycogen synthase kinase-3beta. Li H, et al. Immunology, 2010 Aug. PMID 20497256.Preliminary evidence of ethnic divergence in associations of putative genetic variants for methamphetamine dependence. Bousman CA, et al. Psychiatry Res, 2010 Jul 30. PMID 20478633.Beta-arrestin 2 is required for B1 receptor-dependent post-translational activation of inducible nitric oxide synthase. Kuhr FK, et al. FASEB J, 2010 Jul. PMID 20228252.Non-visual arrestins are constitutively associated with the centrosome and regulate centrosome function. Shankar H, et al. J Biol Chem, 2010 Mar 12. PMID 20056609.
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