DMTF1 Antibody (monoclonal) (M03)
Mouse monoclonal antibody raised against a partial recombinant DMTF1.
|Application ||WB, IHC, IF|
|Calculated MW||84471 Da|
|Other Names||Cyclin-D-binding Myb-like transcription factor 1, hDMTF1, Cyclin-D-interacting Myb-like protein 1, hDMP1, DMTF1, DMP1|
|Target/Specificity||DMTF1 (NP_066968, 661 a.a. ~ 760 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||DMTF1 Antibody (monoclonal) (M03) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder. Liu Y, et al. Mol Psychiatry, 2010 Mar 30. PMID 20351715.Role of DMP1 and its future in lung cancer diagnostics. Sugiyama T, et al. Expert Rev Mol Diagn, 2008 Jul. PMID 18598225.Emerging roles of DMP1 in lung cancer. Inoue K, et al. Cancer Res, 2008 Jun 15. PMID 18559489.The hDMP1 tumor suppressor is a new WT1 target in myeloid leukemias. Tschan MP, et al. Leukemia, 2008 May. PMID 17972942.Mutually exclusive inactivation of DMP1 and ARF/p53 in lung cancer. Mallakin A, et al. Cancer Cell, 2007 Oct. PMID 17936562.
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