GCN5L2 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant GCN5L2.
|Application ||WB, IF|
|Calculated MW||93926 Da|
|Other Names||Histone acetyltransferase KAT2A, General control of amino acid synthesis protein 5-like 2, Histone acetyltransferase GCN5, HsGCN5, Lysine acetyltransferase 2A, STAF97, KAT2A, GCN5, GCN5L2, HGCN5|
|Target/Specificity||GCN5L2 (AAH32743, 738 a.a. ~ 837 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||GCN5L2 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).
GCN5-dependent acetylation of HIV-1 integrase enhances viral integration. Terreni M, et al. Retrovirology, 2010 Mar 12. PMID 20226045.Gcn5 and SAGA regulate shelterin protein turnover and telomere maintenance. Atanassov BS, et al. Mol Cell, 2009 Aug 14. PMID 19683498.Defining the human deubiquitinating enzyme interaction landscape. Sowa ME, et al. Cell, 2009 Jul 23. PMID 19615732.GCN5-mediated transcriptional control of the metabolic coactivator PGC-1beta through lysine acetylation. Kelly TJ, et al. J Biol Chem, 2009 Jul 24. PMID 19491097.Acetylation by GCN5 regulates CDC6 phosphorylation in the S phase of the cell cycle. Paolinelli R, et al. Nat Struct Mol Biol, 2009 Apr. PMID 19343071.
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