HOP Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant HOP.
|Application ||WB, E|
|Other Names||Homeodomain-only protein, Lung cancer-associated Y protein, Not expressed in choriocarcinoma protein 1, Odd homeobox protein 1, HOPX, HOD, HOP, LAGY, NECC1, OB1|
|Target/Specificity||HOP (AAH14225, 1 a.a. ~ 73 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||HOP Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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The protein encoded by this gene is a homeodomain protein that lacks certain conserved residues required for DNA binding. It was reported that choriocarcinoma cell lines and tissues failed to express this gene, which suggested the possible involvement of this gene in malignant conversion of placental trophoblasts. Studies in mice suggest that this protein may interact with serum response factor (SRF) and modulate SRF-dependent cardiac-specific gene expression and cardiac development. Multiple alternatively spliced transcript variants have been identified for this gene.
Expression of the homeobox gene, HOPX, is modulated by cell differentiation in human keratinocytes and is involved in the expression of differentiation markers. Yang JM, et al. Eur J Cell Biol, 2010 Jul. PMID 20226564.Homeobox gene HOPX is epigenetically silenced in human uterine endometrial cancer and suppresses estrogen-stimulated proliferation of cancer cells by inhibiting serum response factor. Yamaguchi S, et al. Int J Cancer, 2009 Jun 1. PMID 19173292.Regulation of survival in adult hippocampal and glioblastoma stem cell lineages by the homeodomain-only protein HOP. De Toni A, et al. Neural Dev, 2008 May 28. PMID 18507846.HOP/OB1/NECC1 promoter DNA is frequently hypermethylated and involved in tumorigenic ability in esophageal squamous cell carcinoma. Yamashita K, et al. Mol Cancer Res, 2008 Jan. PMID 18234960.Importance of the C-terminal domain of Harc for binding to Hsp70 and Hop as well as its response to heat shock. Cartledge K, et al. Biochemistry, 2007 Dec 25. PMID 18052042.
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