ING3 Antibody (monoclonal) (M02)
Mouse monoclonal antibody raised against a partial recombinant ING3.
|Application ||WB, IF, E|
|Calculated MW||46743 Da|
|Other Names||Inhibitor of growth protein 3, p47ING3, ING3|
|Target/Specificity||ING3 (NP_938008, 1 a.a. ~ 92 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||ING3 Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed.
The tumor suppressor ING3 is degraded by SCF(Skp2)-mediated ubiquitin-proteasome system. Chen G, et al. Oncogene, 2010 Mar 11. PMID 19935701.High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility. Maestrini E, et al. Mol Psychiatry, 2010 Sep. PMID 19401682.Downregulation of ING3 mRNA expression predicts poor prognosis in head and neck cancer. Gunduz M, et al. Cancer Sci, 2008 Mar. PMID 18081876.Prognostic significance of nuclear ING3 expression in human cutaneous melanoma. Wang Y, et al. Clin Cancer Res, 2007 Jul 15. PMID 17634537.ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression. Shi X, et al. Nature, 2006 Jul 6. PMID 16728974.
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