KHSRP Antibody (monoclonal) (M09)
Mouse monoclonal antibody raised against a partial recombinant KHSRP.
|Application ||IHC, E|
|Calculated MW||73115 Da|
|Other Names||Far upstream element-binding protein 2, FUSE-binding protein 2, KH type-splicing regulatory protein, KSRP, p75, KHSRP, FUBP2|
|Target/Specificity||KHSRP (NP_003676, 151 a.a. ~ 239 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||KHSRP Antibody (monoclonal) (M09) is for research use only and not for use in diagnostic or therapeutic procedures.|
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The KHSRP gene encodes a multifunctional RNA-binding protein implicated in a variety of cellular processes, including transcription, alternative pre-mRNA splicing, and mRNA localization (Min et al., 1997 [PubMed 9136930]; Gherzi et al., 2004 [PubMed 15175153]).
Antagonistic role of hnRNP A1 and KSRP in the regulation of let-7a biogenesis. Michlewski G, et al. Nat Struct Mol Biol, 2010 Aug. PMID 20639884.Dishevelled-KSRP complex regulates Wnt signaling through post-transcriptional stabilization of beta-catenin mRNA. Bikkavilli RK, et al. J Cell Sci, 2010 Apr 15. PMID 20332102.KSRP-PMR1-exosome association determines parathyroid hormone mRNA levels and stability in transfected cells. Nechama M, et al. BMC Cell Biol, 2009 Sep 23. PMID 19775426.Overexpression of far upstream element binding proteins: a mechanism regulating proliferation and migration in liver cancer cells. Malz M, et al. Hepatology, 2009 Oct. PMID 19585652.The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs. Trabucchi M, et al. Nature, 2009 Jun 18. PMID 19458619.
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