KLF6 Antibody (monoclonal) (M02)
Mouse monoclonal antibody raised against a partial recombinant KLF6.
|Application ||IF, E|
|Calculated MW||31865 Da|
|Other Names||Krueppel-like factor 6, B-cell-derived protein 1, Core promoter element-binding protein, GC-rich sites-binding factor GBF, Proto-oncogene BCD1, Suppressor of tumorigenicity 12 protein, Transcription factor Zf9, KLF6, BCD1, COPEB, CPBP, ST12|
|Target/Specificity||KLF6 (NP_001291, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||KLF6 Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures.|
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This gene encodes a member of the Kruppel-like family of transcription factors. The zinc finger protein is a transcriptional activator, and functions as a tumor suppressor. Multiple transcript variants encoding different isoforms have been found for this gene, some of which are implicated in carcinogenesis.
KLF6 Gene and early melanoma development in a collagen I-rich extracellular environment. Huh SJ, et al. J Natl Cancer Inst, 2010 Aug 4. PMID 20660366.A Large-scale genetic association study of esophageal adenocarcinoma risk. Liu CY, et al. Carcinogenesis, 2010 Jul. PMID 20453000.New genetic associations detected in a host response study to hepatitis B vaccine. Davila S, et al. Genes Immun, 2010 Apr. PMID 20237496.Nuclear expression of KLF6 tumor suppressor factor is highly associated with overexpression of ERBB2 oncoprotein in ductal breast carcinomas. Gehrau RC, et al. PLoS One, 2010 Jan 28. PMID 20126619.Tumor suppressor activity of KLF6 mediated by downregulation of the PTTG1 oncogene. Lee UE, et al. FEBS Lett, 2010 Mar 5. PMID 20116377.
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