KPNA5 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant KPNA5.
|Application ||WB, E|
|Calculated MW||60349 Da|
|Other Names||Importin subunit alpha-6, Karyopherin subunit alpha-5, KPNA5|
|Target/Specificity||KPNA5 (AAH47409.1, 1 a.a. ~ 539 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||KPNA5 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC) which consists of 60-100 proteins and is probably 120 million daltons in molecular size. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion; larger molecules are transported by an active process. Most nuclear proteins contain short basic amino acid sequences known as nuclear localization signals (NLSs). KPNA5 protein belongs to the importin alpha protein family and is thought to be involved in NLS-dependent protein import into the nucleus.
Probing the specificity of binding to the major nuclear localization sequence-binding site of importin-alpha using oriented peptide library screening. Yang SN, et al. J Biol Chem, 2010 Jun 25. PMID 20406804.Plasmodium circumsporozoite protein promotes the development of the liver stages of the parasite. Singh AP, et al. Cell, 2007 Nov 2. PMID 17981117.Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. Jeronimo C, et al. Mol Cell, 2007 Jul 20. PMID 17643375.Breast cancer metastasis suppressor 1 (BRMS1) is stabilized by the Hsp90 chaperone. Hurst DR, et al. Biochem Biophys Res Commun, 2006 Oct 6. PMID 16919237.A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. Lim J, et al. Cell, 2006 May 19. PMID 16713569.
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