LASS6 Antibody (monoclonal) (M02)
Mouse monoclonal antibody raised against a partial recombinant LASS6.
|Application ||WB, E|
|Calculated MW||44890 Da|
|Other Names||Ceramide synthase 6, CerS6, LAG1 longevity assurance homolog 6, CERS6, LASS6|
|Target/Specificity||LASS6 (NP_982288, 62 a.a. ~ 131 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||LASS6 Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cells. Mesicek J, et al. Cell Signal, 2010 Sep. PMID 20406683.Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.PERK-dependent regulation of ceramide synthase 6 and thioredoxin play a key role in mda-7/IL-24-induced killing of primary human glioblastoma multiforme cells. Yacoub A, et al. Cancer Res, 2010 Feb 1. PMID 20103619.Increased ceramide synthase 2 and 6 mRNA levels in breast cancer tissues and correlation with sphingosine kinase expression. Erez-Roman R, et al. Biochem Biophys Res Commun, 2010 Jan 1. PMID 19912991.Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways. Senkal CE, et al. FASEB J, 2010 Jan. PMID 19723703.
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