MAN1B1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant MAN1B1.
|Application ||WB, IHC, E|
|Calculated MW||79580 Da|
|Other Names||Endoplasmic reticulum mannosyl-oligosaccharide 1, 2-alpha-mannosidase, ER alpha-1, 2-mannosidase, ER mannosidase 1, ERMan1, Man9GlcNAc2-specific-processing alpha-mannosidase, Mannosidase alpha class 1B member 1, MAN1B1|
|Target/Specificity||MAN1B1 (NP_057303, 112 a.a. ~ 211 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||MAN1B1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
Polymorphism in the endoplasmic reticulum mannosidase I (MAN1B1) gene is not associated with liver disease in individuals homozygous for the Z variant of the alpha1-antitrypsin protease inhibitor (PiZZ individuals). Chappell S, et al. Hepatology, 2009 Oct. PMID 19739260.Single nucleotide polymorphism-mediated translational suppression of endoplasmic reticulum mannosidase I modifies the onset of end-stage liver disease in alpha1-antitrypsin deficiency. Pan S, et al. Hepatology, 2009 Jul. PMID 19444872.Theory and computation show that Asp463 is the catalytic proton donor in human endoplasmic reticulum alpha-(1-->2)-mannosidase I. Cant? D, et al. Carbohydr Res, 2008 Sep 8. PMID 18619586.Endoplasmic reticulum (ER) mannosidase I is compartmentalized and required for N-glycan trimming to Man5-6GlcNAc2 in glycoprotein ER-associated degradation. Avezov E, et al. Mol Biol Cell, 2008 Jan. PMID 18003979.Stimulation of ERAD of misfolded null Hong Kong alpha1-antitrypsin by Golgi alpha1,2-mannosidases. Hosokawa N, et al. Biochem Biophys Res Commun, 2007 Oct 26. PMID 17727818.
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