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MYOC Antibody (monoclonal) (M02)

Mouse monoclonal antibody raised against a full-length recombinant MYOC.

  • WB - MYOC Antibody (monoclonal) (M02) AT2962a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (81.18 KDa) .
  • WB - MYOC Antibody (monoclonal) (M02) AT2962a
    Western Blot analysis of MYOC expression in transfected 293T cell line by MYOC monoclonal antibody (M02), clone 2B4.

    Lane 1: MYOC transfected lysate(57 KDa).
    Lane 2: Non-transfected lysate.
  • E - MYOC Antibody (monoclonal) (M02) AT2962a
    Detection limit for recombinant GST tagged MYOC is approximately 0.3ng/ml as a capture antibody.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q99972
Other Accession BC029261
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG2b Kappa
Clone Names 2B4
Calculated MW 56972 Da
Additional Information
Gene ID 4653
Other Names Myocilin, Myocilin 55 kDa subunit, Trabecular meshwork-induced glucocorticoid response protein, Myocilin, N-terminal fragment, Myocilin 20 kDa N-terminal fragment, Myocilin, C-terminal fragment, Myocilin 35 kDa N-terminal fragment, MYOC, GLC1A, TIGR
Target/Specificity MYOC (AAH29261, 1 a.a. ~ 504 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsMYOC Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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MYOC encodes the protein myocilin, which is believed to have a role in cytoskeletal function. MYOC is expressed in many occular tissues, including the trabecular meshwork, and was revealed to be the trabecular meshwork glucocorticoid-inducible response protein (TIGR). The trabecular meshwork is a specialized eye tissue essential in regulating intraocular pressure, and mutations in MYOC have been identified as the cause of hereditary juvenile-onset open-angle glaucoma.


Myocilin and optineurin coding variants in Hispanics of Mexican descent with POAG. McDonald KK, et al. J Hum Genet, 2010 Jul 29. PMID 20668460.Little evidence for association of the glaucoma gene MYOC with open-angle glaucoma. Sohn S, et al. Br J Ophthalmol, 2010 May. PMID 20447966.[Genetic variants of CYP1B1 and WDR36 in the patients with primary congenital glaucoma and primary open angle glaucoma from Saint-Petersburg] Motushchuk AE, et al. Genetika, 2009 Dec. PMID 20198978.Association of POAG risk factors and the Thr377Met MYOC mutation in an isolated Greek population. Wirtz MK, et al. Invest Ophthalmol Vis Sci, 2010 Jun. PMID 20107173.Variable clinical spectrum of the myocilin Gln368X mutation in a Dutch family with primary open angle glaucoma. Hogewind BF, et al. Curr Eye Res, 2010 Jan. PMID 20021252.

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$ 350.00
Cat# AT2962a
Availability: 7-10 days
Bulk Size
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