|Calculated MW||36086 Da|
|Other Names||Necdin, NDN|
|Target/Specificity||NDN (NP_002478, 222 a.a. ~ 321 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||NDN Antibody (monoclonal) (M07) is for research use only and not for use in diagnostic or therapeutic procedures.|
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This intronless gene is located in the Prader-Willi syndrome deletion region. It is an imprinted gene and is expressed exclusively from the paternal allele. Studies in mouse suggest that the protein encoded by this gene may suppress growth in postmitotic neurons.
Necdin: a multi functional protein with potential tumor suppressor role? Chapman EJ, et al. Mol Carcinog, 2009 Nov. PMID 19626646.[Regulation of neuronal development by the imprinted gene Necdin] Yoshikawa K. No To Hattatsu, 2009 May. PMID 19517793.Nogo-A inhibits necdin-accelerated neurite outgrowth by retaining necdin in the cytoplasm. Liu X, et al. Mol Cell Neurosci, 2009 May. PMID 19386232.A common variant in DRD3 receptor is associated with autism spectrum disorder. de Krom M, et al. Biol Psychiatry, 2009 Apr 1. PMID 19058789.Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. Lu Y, et al. J Lipid Res, 2008 Dec. PMID 18660489.
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