NKX6-1 Antibody (monoclonal) (M02)
Mouse monoclonal antibody raised against a full length recombinant NKX6-1.
|Calculated MW||37849 Da|
|Other Names||Homeobox protein Nkx-61, Homeobox protein NK-6 homolog A, NKX6-1, NKX6A|
|Target/Specificity||NKX6-1 (NP_006159, 191 a.a. ~ 275 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||NKX6-1 Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
In the pancreas, NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription regulator that binds to AT-rich sequences within the promoter region of target genes Iype et al. (2004) [PubMed 15056733].
Distinct regulation of hepatic nuclear factor 1alpha by NKX6.1 in pancreatic beta cells. Donelan W, et al. J Biol Chem, 2010 Apr 16. PMID 20106981.Alterations of gastric homeoprotein expression in Helicobacter pylori infection, incisural antralisation, and intestinal metaplasia. Zhu S, et al. Dig Dis Sci, 2009 May. PMID 18754095.Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1. Schisler JC, et al. Mol Cell Biol, 2008 May. PMID 18347054.Association studies of variants in the genes involved in pancreatic beta-cell function in type 2 diabetes in Japanese subjects. Yokoi N, et al. Diabetes, 2006 Aug. PMID 16873704.Differentiation of insulin-producing cells from human neural progenitor cells. Hori Y, et al. PLoS Med, 2005 Apr. PMID 15839736.
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