NUDT5 Antibody (monoclonal) (M04)
Mouse monoclonal antibody raised against a partial recombinant NUDT5.
|Application ||WB, E|
|Calculated MW||24328 Da|
|Other Names||ADP-sugar pyrophosphatase, 8-oxo-dGDP phosphatase, Nucleoside diphosphate-linked moiety X motif 5, Nudix motif 5, YSA1H, NUDT5|
|Target/Specificity||NUDT5 (NP_054861, 120 a.a. ~ 219 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||NUDT5 Antibody (monoclonal) (M04) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
Nudix hydrolases, such as NUDT5, eliminate toxic nucleotide derivatives from the cell and regulate the levels of important signaling nucleotides and their metabolites (McLennan, 1999 [PubMed 10373642]).
Suppression of mutagenesis by 8-hydroxy-2'-deoxyguanosine 5'-triphosphate (7,8-dihydro-8-oxo-2'-deoxyguanosine 5'-triphosphate) by human MTH1, MTH2, and NUDT5. Hori M, et al. Free Radic Biol Med, 2010 May 1. PMID 20144704.NUDT5 hydrolyzes oxidized deoxyribonucleoside diphosphates with broad substrate specificity. Kamiya H, et al. DNA Repair (Amst), 2009 Oct 2. PMID 19699693.Molecular mechanism of ADP-ribose hydrolysis by human NUDT5 from structural and kinetic studies. Zha M, et al. J Mol Biol, 2008 Jun 6. PMID 18462755.A human protein-protein interaction network: a resource for annotating the proteome. Stelzl U, et al. Cell, 2005 Sep 23. PMID 16169070.Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. Rush J, et al. Nat Biotechnol, 2005 Jan. PMID 15592455.
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