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OCRL Antibody (monoclonal) (M02)

Mouse monoclonal antibody raised against a partial recombinant OCRL.

  • WB - OCRL Antibody (monoclonal) (M02) AT3144a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.08 KDa) .
  • WB - OCRL Antibody (monoclonal) (M02) AT3144a
    OCRL monoclonal antibody (M02), clone 4A6 Western Blot analysis of OCRL expression in Hela S3 NE ( (Cat # AT3144a )
  • WB - OCRL Antibody (monoclonal) (M02) AT3144a
    Western Blot analysis of OCRL expression in transfected 293T cell line by OCRL monoclonal antibody (M02), clone 4A6.

    Lane 1: OCRL transfected lysate(103.2 KDa).
    Lane 2: Non-transfected lysate.
  • IHC - OCRL Antibody (monoclonal) (M02) AT3144a
    Immunoperoxidase of monoclonal antibody to OCRL on formalin-fixed paraffin-embedded human kidney. [antibody concentration 3 ug/ml]
  • E - OCRL Antibody (monoclonal) (M02) AT3144a
    Detection limit for recombinant GST tagged OCRL is approximately 0.1ng/ml as a capture antibody.
  • WB - OCRL Antibody (monoclonal) (M02) AT3144a
    Western blot analysis of OCRL over-expressed 293 cell line, cotransfected with OCRL Validated Chimera RNAi ( (Cat # AT3144a )
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q01968
Other Accession NM_000276
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG2a Kappa
Clone Names 4A6
Calculated MW 104205 Da
Additional Information
Gene ID 4952
Other Names Inositol polyphosphate 5-phosphatase OCRL-1, Lowe oculocerebrorenal syndrome protein, OCRL, INPP5F, OCRL1
Target/Specificity OCRL (NP_000267, 146 a.a. ~ 239 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsOCRL Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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This gene encodes a phosphatase enzyme that is involved in actin polymerization and is found in the trans-Golgi network. Mutations in this gene cause oculocerebrorenal syndrome of Lowe and also Dent disease.


Two closely related endocytic proteins that share a common OCRL-binding motif with APPL1. Swan LE, et al. Proc Natl Acad Sci U S A, 2010 Feb 23. PMID 20133602.Development of a multiplex ligation-dependent probe amplification (MLPA) assay for quantification of the OCRL1 gene. Coutton C, et al. Clin Biochem, 2010 Apr. PMID 20043897.OCRL1 function in renal epithelial membrane traffic. Cui S, et al. Am J Physiol Renal Physiol, 2010 Feb. PMID 19940034.Lowe syndrome patient fibroblasts display Ocrl1-specific cell migration defects that cannot be rescued by the homologous Inpp5b phosphatase. Coon BG, et al. Hum Mol Genet, 2009 Dec 1. PMID 19700499.Locus heterogeneity of Dent's disease: OCRL1 and TMEM27 genes in patients with no CLCN5 mutations. Tosetto E, et al. Pediatr Nephrol, 2009 Oct. PMID 19582483.

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$ 350.00
Cat# AT3144a
Availability: 7-10 days
Bulk Size
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