PDLIM5 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant PDLIM5.
|Application ||WB, IF, E|
|Other Names||PDZ and LIM domain protein 5, Enigma homolog, Enigma-like PDZ and LIM domains protein, PDLIM5, ENH|
|Target/Specificity||PDLIM5 (AAH08741, 1 a.a. ~ 596 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||PDLIM5 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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The protein encoded by this gene is a LIM domain protein. LIM domains are cysteine-rich double zinc fingers composed of 50 to 60 amino acids that are involved in protein-protein interactions. LIM domain-containing proteins are scaffolds for the formation of multiprotein complexes. The proteins are involved in cytoskeleton organization, cell lineage specification, organ development, and oncogenesis. The encoded protein is also a member of the Enigma class of proteins, a family of proteins that possess a 100-amino acid PDZ domain in the N terminus and 1 to 3 LIM domains in the C terminus. Multiple transcript variants encoding different isoforms have been found for this gene, although not all of them have been fully characterized.
Prostate cancer risk-associated variants reported from genome-wide association studies: Meta-analysis and their contribution to genetic Variation. Kim ST, et al. Prostate, 2010 Jun 16. PMID 20564319.Identification of seven new prostate cancer susceptibility loci through a genome-wide association study. Eeles RA, et al. Nat Genet, 2009 Oct. PMID 19767753.Positive association between the PDLIM5 gene and bipolar disorder in the Chinese Han population. Zhao T, et al. J Psychiatry Neurosci, 2009 May. PMID 19448850.Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population. Yosifova A, et al. J Affect Disord, 2009 Sep. PMID 19328558.A case-control association study of the PDLIM5 gene and bipolar disorder in a Sardinian sample. Squassina A, et al. Psychiatr Genet, 2008 Jun. PMID 18496210.
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