PPM1B Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant PPM1B.
|Application ||WB, IF, IP, E|
|Calculated MW||52643 Da|
|Other Names||Protein phosphatase 1B, Protein phosphatase 2C isoform beta, PP2C-beta, PPM1B, PP2CB|
|Target/Specificity||PPM1B (AAH12002, 1 a.a. ~ 192 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||PPM1B Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences.
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.PPM1A and PPM1B act as IKKbeta phosphatases to terminate TNFalpha-induced IKKbeta-NF-kappaB activation. Sun W, et al. Cell Signal, 2009 Jan. PMID 18930133.Phosphatase PPM1A regulates phosphorylation of Thr-186 in the Cdk9 T-loop. Wang Y, et al. J Biol Chem, 2008 Nov 28. PMID 18829461.Functional specialization of beta-arrestin interactions revealed by proteomic analysis. Xiao K, et al. Proc Natl Acad Sci U S A, 2007 Jul 17. PMID 17620599.Large-scale mapping of human protein-protein interactions by mass spectrometry. Ewing RM, et al. Mol Syst Biol, 2007. PMID 17353931.
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