PSCD2 Antibody (monoclonal) (M02)
Mouse monoclonal antibody raised against a partial recombinant CYTH2.
|Application ||WB, IHC, IF, E|
|Calculated MW||46546 Da|
|Other Names||Cytohesin-2, ARF exchange factor, ARF nucleotide-binding site opener, Protein ARNO, PH, SEC7 and coiled-coil domain-containing protein 2, CYTH2, ARNO, PSCD2, PSCD2L|
|Target/Specificity||CYTH2 (NP_059431, 314 a.a. ~ 398 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||PSCD2 Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures.|
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The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. The encoded protein exhibits GEP activity in vitro with ARF1, ARF3, and ARF6 and is 83% homologous to CYTH1. Two transcript variants encoding different isoforms have been found for this gene.
1.ARNO regulates VEGF-dependent tissue responses by stabilizing endothelial VEGFR-2 surface expression.Mannell HK, Pircher J, Chaudhry DI, Alig SK, Koch EG, Mettler R, Pohl U, Krotz F.Cardiovasc Res. 2011 Nov 7.
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