RAP1GA1 Antibody (monoclonal) (M02)
Mouse monoclonal antibody raised against a full length recombinant RAP1GA1.
|Calculated MW||73361 Da|
|Other Names||Rap1 GTPase-activating protein 1, Rap1GAP, Rap1GAP1, RAP1GAP, KIAA0474, RAP1GA1|
|Target/Specificity||RAP1GA1 (AAH54490.1, 1 a.a. ~ 663 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||RAP1GA1 Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Downregulation of Rap1GAP in human tumor cells alters cell/matrix and cell/cell adhesion. Tsygankova OM, et al. Mol Cell Biol, 2010 Jul. PMID 20439492.Downregulation of Rap1GAP through epigenetic silencing and loss of heterozygosity promotes invasion and progression of thyroid tumors. Zuo H, et al. Cancer Res, 2010 Feb 15. PMID 20124489.The ability of GAP1IP4BP to function as a Rap1 GTPase-activating protein (GAP) requires its Ras GAP-related domain and an arginine finger rather than an asparagine thumb. Kupzig S, et al. Mol Cell Biol, 2009 Jul. PMID 19433443.Down-regulation of Rap1GAP via promoter hypermethylation promotes melanoma cell proliferation, survival, and migration. Zheng H, et al. Cancer Res, 2009 Jan 15. PMID 19147557.Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. Enjuanes A, et al. Cancer Res, 2008 Dec 15. PMID 19074885.
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