SUPT5H Antibody (monoclonal) (M04)
Mouse monoclonal antibody raised against a partial recombinant SUPT5H.
|Application ||WB, IF, E|
|Calculated MW||121000 Da|
|Other Names||Transcription elongation factor SPT5, hSPT5, DRB sensitivity-inducing factor 160 kDa subunit, DSIF p160, DRB sensitivity-inducing factor large subunit, DSIF large subunit, Tat-cotransactivator 1 protein, Tat-CT1 protein, SUPT5H, SPT5, SPT5H|
|Target/Specificity||SUPT5H (AAH24203, 981 a.a. ~ 1087 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||SUPT5H Antibody (monoclonal) (M04) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
DSIF, the Paf1 complex, and Tat-SF1 have nonredundant, cooperative roles in RNA polymerase II elongation. Chen Y, et al. Genes Dev, 2009 Dec 1. PMID 19952111.Crystal structure of the human transcription elongation factor DSIF hSpt4 subunit in complex with the hSpt5 dimerization interface. Wenzel S, et al. Biochem J, 2009 Dec 23. PMID 19860741.Repression of RNA polymerase II elongation in vivo is critically dependent on the C-terminus of Spt5. Chen H, et al. PLoS One, 2009 Sep 9. PMID 19742326.Role of human transcription elongation factor DSIF in the suppression of senescence and apoptosis. Komori T, et al. Genes Cells, 2009 Mar. PMID 19210550.Interplay between E-box and NF-kappaB in regulation of A20 gene by DRB sensitivity-inducing factor (DSIF). Amir-Zilberstein L, et al. J Biol Chem, 2008 Jan 18. PMID 17962196.
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