TPMT Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant TPMT.
|Application ||WB, IHC, IF|
|Calculated MW||28180 Da|
|Other Names||Thiopurine S-methyltransferase, Thiopurine methyltransferase, TPMT|
|Target/Specificity||TPMT (AAH05339, 1 a.a. ~ 245 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||TPMT Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals. A pseudogene for this locus is located on chromosome 18q.
1.S-adenosylmethionine regulates thiopurine methyltransferase activity and decreases 6-mercaptopurine cytotoxicity in MOLT lymphoblasts.Milek M, Karas Kuzelicki N, Smid A, Mlinaric-Rascan I.Biochem Pharmacol. 2009 Jun 15;77(12):1845-53. Epub 2009 Mar 19.2.A novel gene delivery system for stable transfection of thiopurine-S-methyltransferase gene in versatile cell types.Egle R, Milek M, Mlinaric-Rascan I, Fahr A, Kristl J.Eur J Pharm Biopharm. 2008 May;69(1):23-30. Epub 2007 Oct 11.
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