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TPMT Antibody (monoclonal) (M01)

Mouse monoclonal antibody raised against a full length recombinant TPMT.

  • WB - TPMT Antibody (monoclonal) (M01) AT4320a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (52.69 KDa) .
  • WB - TPMT Antibody (monoclonal) (M01) AT4320a
    TPMT monoclonal antibody (M01), clone 1B5 Western Blot analysis of TPMT expression in Jurkat ( (Cat # AT4320a )
  • WB - TPMT Antibody (monoclonal) (M01) AT4320a
    Western Blot analysis of TPMT expression in transfected 293T cell line by TPMT monoclonal antibody (M01), clone 1B5.

    Lane 1: TPMT transfected lysate(28.2 KDa).
    Lane 2: Non-transfected lysate.
  • IHC - TPMT Antibody (monoclonal) (M01) AT4320a
    Immunoperoxidase of monoclonal antibody to TPMT on formalin-fixed paraffin-embedded human spleen. [antibody concentration 1 ug/ml]
  • IF - TPMT Antibody (monoclonal) (M01) AT4320a
    Immunofluorescence of monoclonal antibody to TPMT on HeLa cell. [antibody concentration 10 ug/ml]
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P51580
Other Accession BC005339
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG1 kappa
Clone Names 1B5
Calculated MW 28180 Da
Additional Information
Gene ID 7172
Other Names Thiopurine S-methyltransferase, Thiopurine methyltransferase, TPMT
Target/Specificity TPMT (AAH05339, 1 a.a. ~ 245 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsTPMT Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals. A pseudogene for this locus is located on chromosome 18q.


1.S-adenosylmethionine regulates thiopurine methyltransferase activity and decreases 6-mercaptopurine cytotoxicity in MOLT lymphoblasts.Milek M, Karas Kuzelicki N, Smid A, Mlinaric-Rascan I.Biochem Pharmacol. 2009 Jun 15;77(12):1845-53. Epub 2009 Mar 19.2.A novel gene delivery system for stable transfection of thiopurine-S-methyltransferase gene in versatile cell types.Egle R, Milek M, Mlinaric-Rascan I, Fahr A, Kristl J.Eur J Pharm Biopharm. 2008 May;69(1):23-30. Epub 2007 Oct 11.

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$ 350.00
Cat# AT4320a
Availability: 7-10 days
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