HIST1H2BM Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
|Application ||WB, E|
|Other Accession||P02283, P57053, Q9PSW9, P0C1H5, P0C1H4, Q6PC60, Q8CGP0, Q8N257, Q9D2U9, Q5QNW6, Q64524, Q16778, Q64525, Q00715, Q5BJA5, P0C1H3, P62808, Q8CGP2, P23527, Q99877, Q32L48, P10854, Q99880, Q8CGP1, O60814, Q2M2T1, P06899, Q64478, Q93079, P10853, P58876, Q6ZWY9|
|Predicted||Xenopus, Mouse, Rat, Bovine, Chicken, Zebrafish, Drosophila|
|Calculated MW||H=14;M=14 KDa|
|Antigen Region||44-78 aa|
|Other Names||Histone H2B type 1-M, Histone H2Be, H2B/e, HIST1H2BM, H2BFE|
|Target/Specificity||This HIST1H2BM antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 44-78 amino acids from the Central region of human HIST1H2BM.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HIST1H2BM Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|
|Cellular Location||Nucleus. Chromosome.|
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Provided below are standard protocols that you may find useful for product applications.
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Albig W.,et al.Hum. Genet. 101:284-294(1997).
Marzluff W.F.,et al.Genomics 80:487-498(2002).
Mungall A.J.,et al.Nature 425:805-811(2003).
Lubec G.,et al.Submitted (MAR-2007) to UniProtKB.
Cheung W.L.,et al.Cell 113:507-517(2003).
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