|Other Names||Fibroblast growth factor 2, FGF-2, Basic fibroblast growth factor, bFGF, Heparin-binding growth factor 2, HBGF-2, FGF2, FGFB|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:8663044). Also acts as an integrin ligand which is required for FGF2 signaling (PubMed:28302677). Binds to integrin ITGAV:ITGB3 (PubMed:28302677). Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration (PubMed:8663044, PubMed:28302677). Functions as a potent mitogen in vitro (PubMed:3732516, PubMed:3964259). Can induce angiogenesis (PubMed:23469107, PubMed:28302677).|
|Cellular Location||Secreted. Nucleus. Note=Exported from cells by an endoplasmic reticulum (ER)/Golgi-independent mechanism Unconventional secretion of FGF2 occurs by direct translocation across the plasma membrane. Binding of exogenous FGF2 to FGFR facilitates endocytosis followed by translocation of FGF2 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as CEP57|
|Tissue Location||Expressed in granulosa and cumulus cells. Expressed in hepatocellular carcinoma cells, but not in non- cancerous liver tissue.|
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The protein encoded by this gene is a member of thefibroblast growth factor (FGF) family. FGF family members bindheparin and possess broad mitogenic and angiogenic activities. Thisprotein has been implicated in diverse biological processes, suchas limb and nervous system development, wound healing, and tumorgrowth. The mRNA for this gene contains multiple polyadenylationsites, and is alternatively translated from non-AUG (CUG) and AUGinitiation codons, resulting in five different isoforms withdistinct properties. The CUG-initiated isoforms are localized inthe nucleus and are responsible for the intracrine effect, whereas,the AUG-initiated form is mostly cytosolic and is responsible forthe paracrine and autocrine effects of this FGF. [provided byRefSeq].
Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :Harfouche, G., et al. Stem Cells 28(9):1639-1648(2010)Nikopensius, T., et al. Birth Defects Res. Part A Clin. Mol. Teratol. 88(9):748-756(2010)Markowska, A.I., et al. J. Exp. Med. 207(9):1981-1993(2010)Arnaud, E., et al. Mol. Cell. Biol. 19(1):505-514(1999)
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