|Other Names||Metalloproteinase inhibitor 4, Tissue inhibitor of metalloproteinases 4, TIMP-4, TIMP4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7 and MMP- 9.|
|Tissue Location||Abundant in heart and present at low levels in many other tissues|
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Provided below are standard protocols that you may find useful for product applications.
This gene belongs to the TIMP gene family. The proteinsencoded by this gene family are inhibitors of the matrixmetalloproteinases, a group of peptidases involved in degradationof the extracellular matrix. The secreted, netrin domain-containingprotein encoded by this gene is involved in regulation of plateletaggregation and recruitment and may play role in hormonalregulation and endometrial tissue remodeling.
Nalpas, B., et al. Gut 59(8):1120-1126(2010)Bailey, S.D., et al. Diabetes Care (2010) In press :Wojciechowski, R., et al. Invest. Ophthalmol. Vis. Sci. (2010) In press :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Liss, M., et al. Am. J. Pathol. 175(3):940-946(2009)
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