|Other Names||Cystatin-8, Cystatin-related epididymal spermatogenic protein, CST8, CRES|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Performs a specialized role during sperm development and maturation.|
|Tissue Location||Proximal caput region of the epididymis. Lower expression in the testis. Within the testis it is localized to the elongating spermatids, whereas within the epididymis it is exclusively synthesized by the proximal caput epithelium|
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The cystatin superfamily encompasses proteins that containmultiple cystatin-like sequences. Some of the members are activecysteine protease inhibitors, while others have lost or perhapsnever acquired this inhibitory activity. There are three inhibitoryfamilies in the superfamily, including the type 1 cystatins(stefins), type 2 cystatins and the kininogens. The type 2 cystatinproteins are a class of cysteine proteinase inhibitors found in avariety of human fluids and secretions. The cystatin locus onchromosome 20 contains the majority of the type 2 cystatin genesand pseudogenes. This gene is located in the cystatin locus andencodes a protein similar to type 2 cystatins. The protein exhibitshighly tissue-specific expression in the reproductive tract,suggesting implicit roles in reproduction. Alternative splicingidentified in mouse is suggested in human based on EST evidence butthe full-length nature of putative variants has not beendetermined.
Frygelius, J., et al. Evol. Dev. 12(3):329-342(2010)Chapuis, J., et al. Mol. Psychiatry 14(11):1004-1016(2009)Lamesch, P., et al. Genomics 89(3):307-315(2007)Ramachandran, P., et al. J. Proteome Res. 5(6):1493-1503(2006)Wassler, M., et al. Biol. Reprod. 67(3):795-803(2002)
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