|Other Accession||NP_009218.2, NP_000893.2, NP_009219.2, NP_009220.2|
|Other Names||Neprilysin, Atriopeptidase, Common acute lymphocytic leukemia antigen, CALLA, Enkephalinase, Neutral endopeptidase 2411, NEP, Neutral endopeptidase, Skin fibroblast elastase, SFE, CD10, MME, EPN|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids (PubMed:15283675, PubMed:8168535). Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (PubMed:17101991). Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (PubMed:15283675). Involved in the degradation of atrial natriuretic factor (ANF) (PubMed:2531377, PubMed:2972276). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (PubMed:20876573).|
|Cellular Location||Cell membrane; Single-pass type II membrane protein|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
This gene encodes a common acute lymphocytic leukemiaantigen that is an important cell surface marker in the diagnosisof human acute lymphocytic leukemia (ALL). This protein is presenton leukemic cells of pre-B phenotype, which represent 85% of casesof ALL. This protein is not restricted to leukemic cells, however,and is found on a variety of normal tissues. It is a glycoproteinthat is particularly abundant in kidney, where it is present on thebrush border of proximal tubules and on glomerular epithelium. Theprotein is a neutral endopeptidase that cleaves peptides at theamino side of hydrophobic residues and inactivates several peptidehormones including glucagon, enkephalins, substance P, neurotensin,oxytocin, and bradykinin. This gene, which encodes a 100-kD type IItransmembrane glycoprotein, exists in a single copy of greater than45 kb. The 5' untranslated region of this gene is alternativelyspliced, resulting in four separate mRNA transcripts. The codingregion is not affected by alternative splicing. [provided byRefSeq].
Wang, S., et al. J. Neurochem. 115(1):47-57(2010)Ikenaga, N., et al. Gastroenterology 139(3):1041-1051(2010)Kim, H.S., et al. Histopathology 56(6):708-719(2010)Toussaint, J., et al. PLoS ONE 5 (8) (2010) :Cui, L., et al. PLoS ONE 5 (8), E12121 (2010) :
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.